Dataset Information

Study on the inhibitory effect and mechanism of VOCs of a deep-sea bacteria on Pseudomonas aeruginosa

ABSTRACT: In order to elucidate the potential mechanism of resistance of active substances to PAO1, we performed a 4D Lable Free proteomic analysis to compare the differentially expressed proteins of PAO1 under the stress of active substances.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Pseudomonas Aeruginosa Pao1

SUBMITTER: hu yuanyuan

LAB HEAD: Yuanyuan Hu

PROVIDER: PXD045249 | Pride | 2024-06-16

REPOSITORIES: Pride

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Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa PAO1.

Hu Yuanyuan Y Liu Ge G Sun Chaomin C Wu Shimei S

Marine drugs 20240520 5

The deep-sea bacterium Spongiibacter nanhainus CSC3.9 has significant inhibitory effects on agricultural pathogenic fungi and human pathogenic bacteria, especially Pseudomonas aeruginosa, the notorious multidrug-resistant pathogen affecting human public health. We demonstrate that the corresponding antibacterial agents against P. aeruginosa PAO1 are volatile organic compounds (VOCs, namely VOC-3.9). Our findings show that VOC-3.9 leads to the abnormal cell division of P. ...[more]

PMID: 38786624

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Project description:Pesticides are chemical compounds widely used in agriculture to control pests, since the 1960s. Regardless of its specific targets, such substances, unfortunately, can reach the human organism, and negative cumulative effects have been reported in people worldwide. Chronic exposure to pesticides has been discussed as a significant risk factor for the development of cancer, including breast tumors. Breast cancer is the most common malignant neoplasia that affects women worldwide, whose origin is mostly connected to life habits and the environment, and to a lesser extent to inheritable genetic mechanisms. Therefore, the contribution of substances as pesticides, that are present in the environment continuously, may have a pivotal role in the genesis breast cancer, especially in geographic areas in which women are important players in the rural work and are in direct contact with these compounds. In vitro and experimental studies have broadly reported the mechanisms triggered by pesticides that contribute to breast carcinogenesis, which fall essentially within DNA damage-based events in association with hormones deregulation and rising of metabolites that activate oncogenes (Alleva et al., 2018, BRADLOW et al., 1995). However, few is known about how these mechanisms are connected, as well as the manner that they can correlate with disease prognosis and clinicopathological features in human breast cancer as a result of the toxic consequences of pesticide exposure. In the last years, aiming to expand the knowledge about beyond isolated biological findings, high throughput molecular approaches combined with bioinformatics designs raised as powerful tools to understand breast cancer behavior and biology. Thereby, it was possible to broadcast that breast cancer is a very complex disease, and that distinct mechanisms are activated depending on specific clinicopathological characteristics. As far as we know, there are still no studies reporting the use of proteomics-based strategies to assess the impact of chronic pesticide exposure in women with breast cancer. To fill this gap, the present study proposes a toxicoproteomics perspective to investigate the systemic profile of differentially expressed proteins in the blood of breast cancer patients chronically exposed to pesticides, by using a high-throughput label-free proteomic strategy, and provide an integrative clinicopathological view based on bioinformatics approaches and validation experiments.

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	BE212LQ_Low.raw	Raw
	BE212LQ_NC.raw	Raw
	SEARCH.zip	Other
	checksum.txt	Txt

Dataset Information

Study on the inhibitory effect and mechanism of VOCs of a deep-sea bacteria on Pseudomonas aeruginosa

Dataset's files

Publications

Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of <i>Pseudomonas aeruginosa</i> PAO1.

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