Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Dendritic Cell, Cell Culture
DISEASE(S): Disease Free
SUBMITTER: Berend Gagestein
LAB HEAD: Mario van der Stelt
PROVIDER: PXD033831 | Pride | 2023-04-28
REPOSITORIES: Pride
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Angewandte Chemie (International ed. in English) 20220808 38
In the field of lipid research, bioorthogonal chemistry has made the study of lipid uptake and processing in living systems possible, whilst minimising biological properties arising from detectable pendant groups. To allow the study of unsaturated free fatty acids in live cells, we here report the use of sterculic acid, a 1,2-cyclopropene-containing oleic acid analogue, as a bioorthogonal probe. We show that this lipid can be readily taken up by dendritic cells without toxic side effects, and th ...[more]