Dataset Information

Identification of mouse lncRNA ENSMUST00000219456(GM32255) interacting proteins in HL-1 cardiomyocytes by pull-down assays coupled to MS

ABSTRACT: In this study, pull down assays combined with mass spectrometry analysis were performed in HL-1 cardiomyocytes transfected with control plasmid (OE-Vector) or LOC107984012-overexpression plasmid to identify the repertoire of LOC107984012 interacting proteins.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Jingjing Wan

LAB HEAD: Jingjing Wan

PROVIDER: PXD036966 | Pride | 2024-01-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Con_Gm32255_Antisense_MS_Rawdata.raw	Raw
	Con_Gm32255_Antisense_Proteins.csv	Csv
	Con_Gm32255_Antisense_protein-peptides.csv	Csv
	Con_Gm32255_Sense_MS_Rawdata.raw	Raw
	Con_Gm32255_Sense_Proteins.csv	Csv

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Publications

Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456.

Wan Jingjing J Zhang Zhen Z Wu Chennan C Tian Saisai S Zang Yibei Y Jin Ge G Sun Qingyan Q Wang Pin P Luan Xin X Yang Yili Y Zhan Xuelin X Ye Lingyu Linda LL Duan Dayue Darrel DD Liu Xia X Zhang Weidong W

Signal transduction and targeted therapy 20231019 1

Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction (MI) heart failure (HF). Here, we report a novel small molecule HHQ16, an optimized derivative of astragaloside IV, which effectively reversed infarction-induced myocardial remodeling and improved cardiac function by directly acting on the cardiomyocyte to reverse hypertrophy. The effect of HHQ16 was associated with a strong inhibition of a newly discovered Egr2-affiliated transcript lnc9456 in t ...[more]

PMID: 37857609

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