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Workingtitle HLA-B*57:01 CBZ EPX impact

ABSTRACT: Impact of CBZ and EPX treatment on a with HLA-B*57:01 tranduced cell line compared to the parental cell line

INSTRUMENT(S): Orbitrap Exploris 240

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Cell Culture

SUBMITTER: Florian Stieglitz

LAB HEAD: Christina Bade-Döding

PROVIDER: PXD037502 | Pride | 2023-05-10

REPOSITORIES: Pride

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			Action	DRS
	E-FA_04-22-Gel-1_1A.raw	Raw
	E-FA_04-22-Gel-1_1B.raw	Raw
	E-FA_04-22-Gel-1_1C.raw	Raw
	E-FA_04-22-Gel-1_1D.raw	Raw
	E-FA_04-22-Gel-1_2A.raw	Raw

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Publications

HLA-B*57:01/Carbamazepine-10,11-Epoxide Association Triggers Upregulation of the NFκB and JAK/STAT Pathways.

Haukamp Funmilola Josephine FJ Hartmann Zoe Maria ZM Pich Andreas A Kuhn Joachim J Blasczyk Rainer R Stieglitz Florian F Bade-Döding Christina C

Cells 20230221 5

Measure of drug-mediated immune reactions that are dependent on the patient's genotype determine individual medication protocols. Despite extensive clinical trials prior to the license of a specific drug, certain patient-specific immune reactions cannot be reliably predicted. The need for acknowledgement of the actual proteomic state for selected individuals under drug administration becomes obvious. The well-established association between certain HLA molecules and drugs or their metabolites ha ...[more]

PMID: 36899812

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