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APMS analysis of endogenous mGlu2 receptor interactome in mice prefrontal cortex

ABSTRACT: Metabotropic glutamate receptor 2 (mGlu2) attracts particular attention as a possible target for a new class of antipsychotics. However, the signaling pathways transducing the effects of mGlu2 in the brain remain poorly characterized. Here, we addressed this issue by identifying native mGlu2 interactome in mouse prefrontal cortex. Nanobody-based affinity purification and mass spectrometry identified 149 candidate mGlu2 partners.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Prefrontal Cortex

SUBMITTER: Franck Vandermoere

LAB HEAD: Franck Vandermoere

PROVIDER: PXD038192 | Pride | 2024-01-29

REPOSITORIES: Pride

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			Action	DRS
	Maxquant_band_1.zip	Other
	Maxquant_band_2.zip	Other
	Maxquant_band_3.zip	Other
	Maxquant_band_4.zip	Other
	Maxquant_band_5.zip	Other

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