Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Leishmania Major Strain Friedlin
SUBMITTER: Tiago Serafim
LAB HEAD: Jesus Valenzuela
PROVIDER: PXD038652 | Pride | 2023-08-20
REPOSITORIES: Pride
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Deamidation__NQ_Sites.txt | Txt | |||
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Serafim Tiago D TD Iniguez Eva E Barletta Ana Beatriz F ABF Cecilio Pedro P Doehl Johannes S P JSP Short Mara M Lack Justin J Nair Vinod V Disotuar Maria M Wilson Timothy T Coutinho-Abreu Iliano V IV Meneses Claudio C Andersen John J Alves E Silva Thiago Luiz TL Oliveira Fabiano F Vega-Rodriguez Joel J Barillas-Mury Carolina C Ribeiro José M C JMC Beverley Stephen M SM Kamhawi Shaden S Valenzuela Jesus G JG
Nature 20231025 7985
Host factors that mediate Leishmania genetic exchange are not well defined. Here we demonstrate that natural IgM (IgMn)<sup>1-4</sup> antibodies mediate parasite genetic exchange by inducing the transient formation of a spherical parasite clump that promotes parasite fusion and hybrid formation. We establish that IgMn from Leishmania-free animals binds to the surface of Leishmania parasites to induce significant changes in the expression of parasite transcripts and proteins. Leishmania binding t ...[more]