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Human ESCO2-interacting proteins in response to DNA damage

ABSTRACT: We used IP-MS to detected the proteins that interact with ESCO2 in response to DNA damage.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Kidney

SUBMITTER: Jianfeng Fu

LAB HEAD: Xiaofeng Zheng

PROVIDER: PXD039072 | Pride | 2023-10-24

REPOSITORIES: Pride

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			Action	DRS
	FJF_20201007_F2_BLEO.mzML	Mzml
	FJF_20201007_F2_BLEO.mzid.gz	Mzid
	FJF_20201007_F2_BLEO.raw	Raw

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Publications

ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex.

Fu Jianfeng J Zhou Siru S Xu Huilin H Liao Liming L Shen Hui H Du Peng P Zheng Xiaofeng X

Nucleic acids research 20230801 14

53BP1 is primarily known as a key regulator in DNA double-strand break (DSB) repair. However, the mechanism of DSB-triggered cohesin modification-modulated chromatin structure on the recruitment of 53BP1 remains largely elusive. Here, we identified acetyltransferase ESCO2 as a regulator for DSB-induced cohesin-dependent chromatin structure dynamics, which promotes 53BP1 recruitment. Mechanistically, in response to DNA damage, ATM phosphorylates ESCO2 S196 and T233. MDC1 recognizes phosphorylated ...[more]

PMID: 37377435

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| S-EPMC7446195 | biostudies-literature

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