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RNxQuest: an extension to the xQuest pipeline enabling analysis of protein-RNA cross-linking/mass spectrometry data

ABSTRACT: The recently introduced cross-linking of isotope-labelled RNA coupled with mass spectrometry (CLIR-MS) technique enables protein-RNA cross-links to be used as precisely localized distance restraints in de novo structural modelling. The novel data type requires a bespoke data analysis approach. The new RNxQuest Python package supports this approach. Here we demonstrate the performance of the new package using a mixture of novel and published datasets.

INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human) Bos Taurus (bovine)

SUBMITTER: Christopher Sarnowski

LAB HEAD: Alexander Leitner

PROVIDER: PXD039754 | Pride | 2023-09-06

REPOSITORIES: Pride

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			Action	DRS
	210301_OE1_csarnowski_2104_1A.raw	Raw
	210301_OE1_csarnowski_2104_1B.raw	Raw
	210301_OE1_csarnowski_2104_1C.raw	Raw
	210301_OE1_csarnowski_2104_1D.raw	Raw
	210301_OE1_csarnowski_2104_1Un.raw	Raw

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