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Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation

ABSTRACT: Chemical cross-linking coupled to mass spectrometry was used to study the interaction between IgG-type antibodies and the neonatal Fc receptor (FcRn). Different cross-linking chemistries were used, including disuccinimidyl suberate (DSS); a combination of pimelic dihydrazide (PDH) in combination with the zero-length cross-linking reagent, DMTMM; and the Xplex method using hexanediamine and N-hydroxybenzotriazole.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Alexander Leitner

LAB HEAD: Alexander Leitner

PROVIDER: PXD044405 | Pride | 2024-12-03

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	File_list_FcRn.xlsx	Xlsx
	XL_identifications_FcRn.xlsx	Xlsx
	checksum.txt	Txt
	ejensen_C1803_203.raw	Raw
	ejensen_C1803_204.raw	Raw

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