Proteomic profile of P. brasiliensis yeasts recovered from granulomatous lesions of C57BL/6 WT mice
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ABSTRACT: C57BL/6 WT mice were infected with 1x10^6 P. brasiliensis yeasts. After 8 weeks and 12 weeks of infection the animals were euthanized and the granulomatous lesions were recovered. Then, the yeasts were recovered and cultivated in a rich medium. After cultivation the yeasts proteins were extracted, digested with trypsin and analyzed by LC-MS/MS. The data show an induced metabolism by the recovered yeasts, with a higher abundance of proteins related to energy metabolism, lipid metabolism, nucleotide metabolism, amino acid metabolism. Additionally there is a higher abundance of some virulence factor
INSTRUMENT(S): Q Exactive
ORGANISM(S): Paracoccidioides Brasiliensis (strain Pb18)
DISEASE(S): Paracoccidioidomycosis
SUBMITTER: Bruno Borges
LAB HEAD: Flávio Vieira Loures
PROVIDER: PXD040829 | Pride | 2023-10-23
REPOSITORIES: Pride
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