Dataset Information

The assessment of hiPSC-derived Neural Stem Cells after a repeated-dose bisphenol A exposure

ABSTRACT: The present study evaluated the effects of a repeated-dose exposure of environmentally relevant BPA concentrations during the in vitro 3D neural induction of human induced pluripotent stem cells (hiPSCs), emulating a chronic exposure scenario. Quantitative proteomics at D21 revealed several differentially abundant proteins across all BPA-treated groups with important functions in NSC proliferation and maintenance.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Bachuki Shashikadze

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD042045 | Pride | 2023-09-06

REPOSITORIES: Pride

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Publications

Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model.

Horánszky Alex A Shashikadze Bachuki B Elkhateib Radwa R Lombardo Salvo Danilo SD Lamberto Federica F Zana Melinda M Menche Jörg J Fröhlich Thomas T Dinnyés András A

Frontiers in cell and developmental biology 20230816

Bisphenol A (BPA) exposure is associated with a plethora of neurodevelopmental abnormalities and brain disorders. Previous studies have demonstrated BPA-induced perturbations to critical neural stem cell (NSC) characteristics, such as proliferation and differentiation, although the underlying molecular mechanisms remain under debate. The present study evaluated the effects of a repeated-dose exposure of environmentally relevant BPA concentrations during the <i>in vitro</i> 3D neural induction of ...[more]

PMID: 37664457

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