Proteomics

Dataset Information

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Protein degradation targets in hippocampus and retrosplenial cortex of the aged brain


ABSTRACT: This project examined changes in degradation-specific K48 polyubiquitination in the hippocampus across the lifespan and during memory formation in old age in rats.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Keith Ray  

LAB HEAD: Timothy J. Jarome

PROVIDER: PXD047288 | Pride | 2024-08-01

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
230501_Jarome2_A1_01.mgf Mgf
230501_Jarome2_A1_01.msf Msf
230501_Jarome2_A1_01.msfView Msf
230501_Jarome2_A1_01.mzData Other
230501_Jarome2_A1_01.mzML Mzml
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Publications

Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus.

Patrick Morgan B MB   Preveza Natalie J NJ   Kincaid Shannon E SE   Setenet Gueladouan G   Abraham Jennifer R JR   Cummings Adam A   Banani Shifa S   Ray W Keith WK   Helm Richard F RF   Trask Sydney S   Jarome Timothy J TJ  

Brain research bulletin 20240613


The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells and dysregulation of the UPS has been implicated in the pathophysiology of numerous neurodegenerative disorders, including Alzheimer's disease. Further, strong evidence supports a critical role for the UPS in synaptic plasticity and memory formation. However, while proteasome function is known to decrease broadly in the brain across the lifespan, whether it changes in the hippocampus, a region critical fo  ...[more]

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