Dataset Information
Protein degradation targets in hippocampus of the aged brain following context exposure
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Hippocampus
SUBMITTER: 
Keith Ray
LAB HEAD: Timothy J. Jarome
PROVIDER: PXD051644 | Pride | 2024-08-01
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 240316_JaromeMale_M10_01.raw | Raw | |||
| 240316_JaromeMale_M10_02.raw | Raw | |||
| 240316_JaromeMale_M11_01.raw | Raw | |||
| 240316_JaromeMale_M11_02.raw | Raw | |||
| 240316_JaromeMale_M12_01.raw | Raw |
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Publications
Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus.
Brain research bulletin 20240613
The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells and dysregulation of the UPS has been implicated in the pathophysiology of numerous neurodegenerative disorders, including Alzheimer's disease. Further, strong evidence supports a critical role for the UPS in synaptic plasticity and memory formation. However, while proteasome function is known to decrease broadly in the brain across the lifespan, whether it changes in the hippocampus, a region critical fo ...[more]