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Identification of interacting proteins with U4 snRNA with and without USP39

ABSTRACT: RNA splicing and protein degradation systems allow the functional adaptation of the proteome in response to changing cellular contexts. However, the regulatory mechanisms connecting these processes remain poorly understood. Here, we show that impaired spliceosome assembly caused by USP39 deficiency leads to a pathogenic splicing profile characterized by the use of cryptic 5′ splice sites. We performed MS analysis to identify the main interactors of U4 snRNA with and without USP39

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Alfredo Cabrera-Orefice

LAB HEAD: Alfredo Cabrera-Orefice

PROVIDER: PXD050688 | Pride | 2024-09-25

REPOSITORIES: Pride

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			Action	DRS
	JO531_Dikic_U4snRNA_ASoligo_Pulldown_MS_results.xlsx	Xlsx
	P23_048_JO531_10_B.raw	Raw
	P23_048_JO531_10_C.raw	Raw
	P23_048_JO531_10_D.raw	Raw
	P23_048_JO531_10_E.raw	Raw

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