Proteomics

Dataset Information

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Protein degradation targets in the retrosplenial cortex of the female aged brain

ABSTRACT: Samples were the retrosplenial cortex dissected from female Fischer F344 rats that were 3-, 12-, or 23 months old.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brodmann Area 29

SUBMITTER: Keith Ray  

LAB HEAD: Timothy J. Jarome

PROVIDER: PXD051203 | Pride | 2024-08-01

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
240301_JaromeFemaleRSC_A1_01.mgf Mgf
240301_JaromeFemaleRSC_A1_01.msf Msf
240301_JaromeFemaleRSC_A1_01.msfView Msf
240301_JaromeFemaleRSC_A1_01.mzData Other
240301_JaromeFemaleRSC_A1_01.mzML Mzml
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Publications

Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus.

Patrick Morgan B MB   Preveza Natalie J NJ   Kincaid Shannon E SE   Setenet Gueladouan G   Abraham Jennifer R JR   Cummings Adam A   Banani Shifa S   Ray W Keith WK   Helm Richard F RF   Trask Sydney S   Jarome Timothy J TJ  

Brain research bulletin 20240613

The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells and dysregulation of the UPS has been implicated in the pathophysiology of numerous neurodegenerative disorders, including Alzheimer's disease. Further, strong evidence supports a critical role for the UPS in synaptic plasticity and memory formation. However, while proteasome function is known to decrease broadly in the brain across the lifespan, whether it changes in the hippocampus, a region critical fo  ...[more]

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