Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Brodmann Area 29
SUBMITTER: Keith Ray
LAB HEAD: Timothy J. Jarome
PROVIDER: PXD051203 | Pride | 2024-08-01
REPOSITORIES: Pride
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Brain research bulletin 20240613
The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells and dysregulation of the UPS has been implicated in the pathophysiology of numerous neurodegenerative disorders, including Alzheimer's disease. Further, strong evidence supports a critical role for the UPS in synaptic plasticity and memory formation. However, while proteasome function is known to decrease broadly in the brain across the lifespan, whether it changes in the hippocampus, a region critical fo ...[more]