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Linc-ADAIN Pulldown assay in Human Adipocytes.

ABSTRACT: Description: a biotinylated pulldown assay of linc-ADAIN, lincRNA vs Antisense Linc-ADAIN in primary human ASC adipocytes coupled to mass spectrometry (MS).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Adipocyte

SUBMITTER: Rajesh Soni

LAB HEAD: Muredach Patrick Reilly

PROVIDER: PXD051388 | Pride | 2024-10-17

REPOSITORIES: Pride

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			Action	DRS
	MO933.sf3	Other
	MO933_AntisenseLincADAIN.raw	Raw
	MO933_LincADAIN.raw	Raw

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Publications

linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability.

O'Reilly Marcella E ME Ho Sebastian S Coronel Johana J Zhu Lucie L Liu Wen W Xue Chenyi C Kim Eunyoung E Cynn Esther E Matias Caio V CV Soni Rajesh Kumar RK Wang Chen C Ionita-Laza Iuliana I Bauer Robert C RC Ross Leila L Zhang Yiying Y Corvera Silvia S Fried Susan K SK Reilly Muredach P MP

Cell reports 20240514 5

Adipose tissue remodeling and dysfunction, characterized by elevated inflammation and insulin resistance, play a central role in obesity-related development of type 2 diabetes (T2D) and cardiovascular diseases. Long intergenic non-coding RNAs (lincRNAs) are important regulators of cellular functions. Here, we describe the functions of linc-ADAIN (adipose anti-inflammatory), an adipose lincRNA that is downregulated in white adipose tissue of obese humans. We demonstrate that linc-ADAIN knockdown ...[more]

PMID: 38753486

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