Dataset Information

SWATH DIA MS data of human plasma from donors with intervertebral disc degeneration

ABSTRACT: SWATH DIA mass spectometry was peformed on plasma samples from donors with mild or severe intervetebral disc degeneration to identify biomarkers associated with degeneration progression.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Christabel Dube

LAB HEAD: Stephen M. Richardson

PROVIDER: PXD055158 | Pride | 2025-02-14

REPOSITORIES: pride

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Publications

Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration.

Dube Christabel Thembela CT Gilbert Hamish T J HTJ Rabbitte Niamh N Baird Pauline P Patel Sonal S Herrera Jeremy A JA Baricevic-Jones Ivona I Unwin Richard D RD Chan Danny D Gnanalingham Kanna K Hoyland Judith A JA Richardson Stephen M SM

Arthritis research & therapy 20250210 1

<h4>Background</h4>Intervertebral disc (IVD) degeneration is a common cause of low back pain, and the most symptomatic patients with neural compression need surgical intervention to relieve symptoms. Current techniques used to diagnose IVD degeneration, such as magnetic resonance imaging (MRI), do not detect changes in the tissue extracellular matrix (ECM) as degeneration progresses. Improved techniques, such as a combination of tissue and blood biomarkers, are needed to monitor the progression ...[more]

PMID: 39930483

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	DIBBP01_10PR_1.wiff	Wiff
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	DIBBP01_11PR_1.wiff	Wiff