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Mouse gut metagenome

ABSTRACT: Effects of a subchronic and mild social defeat stress on murine cecal microbiota

PROVIDER: PRJDB4063 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR057779.fastq.gz	Fastqsanger.gz
	DRR057780.fastq.gz	Fastqsanger.gz
	DRR057781.fastq.gz	Fastqsanger.gz
	DRR057782.fastq.gz	Fastqsanger.gz
	DRR057783.fastq.gz	Fastqsanger.gz

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mouse gut metagenome

Project description:Effects of a subchronic and mild social defeat stress on murine fecal microbiota

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Expression data from ileum of mice suffered from subchronic and mild social defeat stress

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Project description:We performed high-throughput profiling of gene expression in the mPFC of stress-vulnerable DBA2/J mice subjected to subchronic and mild social defeat stress.DBA mice were subjected to 5-day of social defeat stress and then injected with KDM5C inhibitor (KDM5Ci) or vehicle. After behavioral tests, mice were euthanized for tissue collection. We then conducted the transcriptomics analysis. Our study provided insights into the understanding of the molecular mechanisms underlying stress susceptibility and provide the role of KDM5C in stress-induced behavioral changes.

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Project description:Expression data from ileum of mice suffered from subchronic and mild social defeat stress

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Project description:Transcription profiling by array of ileum from mouse exposed to subchronic and mild social defeat stress

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BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli

Project description:ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the nucleus accumbens (NAc), a key brain reward region, in both chronic cocaine-treated mice and mice that are resilient to chronic social defeat stress. In contrast, no regulation is seen in mice that are susceptible to this chronic stress. Viral-mediated overexpression of Baz1b, along with its associated subunit Smarca5, in mouse NAc is sufficient to potentiate both rewarding responses to cocaine, including cocaine self-administration, and resilience to chronic social defeat stress. However, despite these similar, proreward behavioral effects, genome-wide mapping of BAZ1B in NAc revealed mostly distinct subsets of genes regulated by these chromatin remodeling proteins after chronic exposure to either cocaine or social stress. Together, these findings suggest important roles for BAZ1B and its associated chromatin remodeling complexes in NAc in the regulation of reward behaviors to distinct emotional stimuli and highlight the stimulus-specific nature of the actions of these regulatory proteins. BAZ1B (WSTF) ChIP-seq of mouse. Cocaine vs Saline, 3 biological replicates. In social defeat model: Normal control vs Susceptible vs Resilient, 3 biological replicates.

2016-07-30 | E-GEOD-85005 | biostudies-arrayexpress

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