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Mouse gut metagenome

ABSTRACT: Effects of a subchronic and mild social defeat stress on murine fecal microbiota

PROVIDER: PRJDB4065 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR057789.fastq.gz	Fastqsanger.gz
	DRR057790.fastq.gz	Fastqsanger.gz
	DRR057791.fastq.gz	Fastqsanger.gz
	DRR057792.fastq.gz	Fastqsanger.gz
	DRR057793.fastq.gz	Fastqsanger.gz

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mouse gut metagenome

Project description:Effects of a subchronic and mild social defeat stress on murine cecal microbiota

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Expression data from ileum of mice suffered from subchronic and mild social defeat stress

Project description:This study aimed to investigate the effects of depression on transcriptome in ileum using a subchronic and mild social defeat stress (sCSDS) model. In addition to exhibiting social deficit and hyperphagia-like behavior, the sCSDS mice keep much more water in their body than control mice. In order to investigate the effect of social defeat stress on not only central nervous system but also function of gastrointestinal tract, the gene expression in ileum of stressed mice was compared with control mice. We used microarrays to detail the gene expression after 10 days of social defeat stress and identified distinct classes of down-regulated genes during this process.

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Expression data from ileum of mice suffered from subchronic and mild social defeat stress

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RNA sequencing analysis of gene expression in the mPFC of stressed DBA mice given vehicle of KDM5C inhibitor

Project description:We performed high-throughput profiling of gene expression in the mPFC of stress-vulnerable DBA2/J mice subjected to subchronic and mild social defeat stress.DBA mice were subjected to 5-day of social defeat stress and then injected with KDM5C inhibitor (KDM5Ci) or vehicle. After behavioral tests, mice were euthanized for tissue collection. We then conducted the transcriptomics analysis. Our study provided insights into the understanding of the molecular mechanisms underlying stress susceptibility and provide the role of KDM5C in stress-induced behavioral changes.

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Project description:We performed high-throughput profiling of gene expression in aPVT-projectors in the mPFC of DBA2/J mice subjected to subchronic and mild social defeat stress. DBA mice were subjected to 5-day of social defeat stress and then tested their social interaction and anhedonic state. After behavioral tests, mice were divided into five subtypes: SA, social interaction deficit, ANH: anhedonia, SA:ANH, both social dificit and anhedonia, RES, resilience and non-stressed (NS) control. Mice were euthanized for tissue collection. We then conducted the Immunoprecipitation and RNA-seq. Our study provided insights into the understanding of the molecular mechanisms underlying behavioral heterogeneity.

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Effects of social defeat stress on colonic epithelial transcriptome

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Project description:Expression data from ileum of mice suffered from subchronic and mild social defeat stress

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Project description:Transcription profiling by array of ileum from mouse exposed to subchronic and mild social defeat stress

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BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli

Project description:ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the nucleus accumbens (NAc), a key brain reward region, in both chronic cocaine-treated mice and mice that are resilient to chronic social defeat stress. In contrast, no regulation is seen in mice that are susceptible to this chronic stress. Viral-mediated overexpression of Baz1b, along with its associated subunit Smarca5, in mouse NAc is sufficient to potentiate both rewarding responses to cocaine, including cocaine self-administration, and resilience to chronic social defeat stress. However, despite these similar, proreward behavioral effects, genome-wide mapping of BAZ1B in NAc revealed mostly distinct subsets of genes regulated by these chromatin remodeling proteins after chronic exposure to either cocaine or social stress. Together, these findings suggest important roles for BAZ1B and its associated chromatin remodeling complexes in NAc in the regulation of reward behaviors to distinct emotional stimuli and highlight the stimulus-specific nature of the actions of these regulatory proteins. BAZ1B (WSTF) ChIP-seq of mouse. Cocaine vs Saline, 3 biological replicates. In social defeat model: Normal control vs Susceptible vs Resilient, 3 biological replicates.

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Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix

Project description:We performed RNA-seq in lateral habenula of mice with susceptibility to chronic social defeat stress.

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