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Burkholderia isolated from medicinal plant rhizosphere and bulk soils from the Western Ghats, India

ABSTRACT: Identifying and characterizing antimicrobial producing Burkholderia from the medicinal plant rhizosphere and soils of the Western Ghats, India

PROVIDER: PRJEB43498 | ENA |

REPOSITORIES: ENA

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Bacterial endophytes associated with medicinal plants of the Western Ghats, India

Project description:Culturable diversity of bacterial endophytes associated with medicinal plants of the Western Ghats, India

| PRJEB37902 | ENA

Proteomics of Hypnale hypnale (Hump-nosed pit viper) venom from the Western Ghats of India

Project description:Hypnale hypnale (hump-nosed pit viper) is considered to be one among the medically important venomous snake species of India and Sri Lanka. In the present study, venom proteome profiling of a single Hypnale hypnale from Western Ghats of India was achieved using SDS-PAGE based protein separation followed by LC-MS/MS analysis

2020-03-19 | PXD017592 | Pride

Proteomics of Naja naja venom from the Western Ghats of India

Project description:This project mainly aims to characterize the complex toxic components present in the venom of Indian cobra (Naja naja) from the Western Ghats of India. Naja naja (NN) is native to the Indian subcontinent and is also found in Pakistan, Sri Lanka, Bangladesh and Southern Nepal. It is a highly venomous snake species of genus Naja of the Elapidae family. They are seen in wide habitats like plains, dense or open forests, rocky terrains, wetlands, agricultural lands, and outskirts of villages and even in highly populated urban areas. This species has been included in the ‘Big 4’ category of venomous snake species that accounts for majority of morbidity and mortality cases in India. Therefore, exploring the venom proteome of Naja naja is decisive to develop and design new antivenom and therapeutics against its envenomation. The venom proteome of Naja naja was characterized through various orthogonal separation strategies and identification strategies. In order to achieve this the crude venom components were resolved on a 12% SDS page. Also, the venom was decomplexed through reversed-phase HPLC followed by SDS analysis. Further each of the bands were subjected to in-gel digestion using trypsin, chymotrypsin and V8 proteases. All the digested peptides were then subjected to Q-TOF LC-MS/MS analysis.

2024-06-20 | PXD018936 | Pride

Fangs in the ghats: preclinical insights into the medical importance of endemic pit vipers from the Western Ghats

Project description:The socioeconomic burden of snakebite in India is largely attributed to the ‘big four’ snakes, completely neglecting the considerable impact of envenoming by many other snake species. Bites from the so-called ‘neglected many’ are often treated with a polyvalent antivenom that is manufactured against the ‘big four’ snakes - a strategy that has been widely documented to fail. Yet, specific antivenoms are not commercially manufactured against these snakes. While the medical importance of various species of cobras, saw-scaled vipers, and kraits is very well-known, the clinical impact of pit vipers from the rainforests of the Western Ghats, northeastern India, and Andaman and Nicobar islands has remained elusive. Amongst the 90+ species of snakes found in the Western Ghats, the hump-nosed (Hypnale hypnale), Malabar (Craspedocephalus malabaricus) and bamboo (Craspedocephalus gramineus) pit vipers can potentially inflict clinically severe envenoming in humans. To evaluate the severity of toxicity inflicted by these snakes, we characterised their venom composition, biochemical and pharmacological activities, and toxicity- and morbidity-inducing potentials. Our findings highlight the therapeutic inadequacies of the generic Indian and Hypnale-specific Sri Lankan polyvalent antivenoms in neutralising morbidity and mortality resulting from pit viper envenomings and underscore the need for a regional antivenom therapy in India.

2023-07-20 | PXD039139 | Pride

Venom proteomics of Naja naja of western India origin

Project description:Bites by the Indian spectacled cobra (Naja naja) are widely reported across the Indian subcontinent, with an associated high rate of mortality and morbidity. In western India (WI), the numbers of reported incidents of cobra envenomation are significantly higher than the other snake bites. In this study the venom proteome of WINn was deciphered for the first time using tandem mass spectroscopy analysis.

2019-01-07 | PXD008011 | Pride

Metagenome of Arabian Sea, Western Coast of India

Project description:Metagenome of Arabian Sea, Western Coast of India Metagenome

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OSCC CGH SriLanka vs India

Project description:In Asia, oral cancer (OC) and oral submucous fibrosis (OSF) constitute major health problems linked to use of betel quid. This work performed CGH genome-wide analysis of OC (12 from India, 12 from Sri Lanka) and OSF (6 from India) cases with normal controls.

2011-11-30 | E-MTAB-819 | biostudies-arrayexpress

Microbiome of organic soils from Sikkim, India

Project description:Microbiome of organic soils from Sikkim, India Metagenome

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Project description:Bacterial diversity analysis in rhizosphere of Ficus spp. in Western Ghats, India

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Microarray based Gene expression profiling of Cervical Cancer in India

Project description:This is a study to identify clinically relevant molecular signatures of gene expression in cervical cancer samples fro m patients in India Keywords: Cancer versus normal study

2007-03-01 | GSE4482 | GEO

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