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Heart failure severity closely correlates with intestinal dysbiosis and subsequent metabolomic alterations

ABSTRACT: Gut microbiome and metabolome of transverse aortic constriction (TAC) induced mice

PROVIDER: PRJEB45229 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR5956780_1.fastq.gz	Fastqsanger.gz
	ERR5956780_2.fastq.gz	Fastqsanger.gz
	ERR5956790_1.fastq.gz	Fastqsanger.gz
	ERR5956790_2.fastq.gz	Fastqsanger.gz
	ERR5956800_1.fastq.gz	Fastqsanger.gz

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Heart failure severity closely correlates with intestinal dysbiosis and subsequent metabolomic alterations

Project description:Gut microbiome and metabolome of transverse aortic constriction (TAC) induced mice

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Heart Failure Severity Closely Correlates with Intestinal Dysbiosis and Subsequent Metabolomic Alterations.

Project description:Growing evidence suggests an altered gut microbiome in patients with heart failure (HF). However, the exact interrelationship between microbiota, HF, and its consequences on the metabolome are still unknown. We thus aimed here to decipher the association between the severity and progression of HF and the gut microbiome composition and circulating metabolites. Using a mouse model of transverse aortic constriction (TAC), gut bacterial diversity was found to be significantly lower in mice as early as day 7 post-TAC compared to Sham controls (p = 0.03), with a gradual progressive decrease in alpha-diversity on days 7, 14, and 42 (p = 0.014, p = 0.0016, p = 0.0021) compared to day 0, which coincided with compensated hypertrophy, maladaptive hypertrophy, and overtly failing hearts, respectively. Strikingly, segregated analysis based on the severity of the cardiac dysfunction (EF < 40% vs. EF 40−55%) manifested marked differences in the abundance and the grouping of several taxa. Multivariate analysis of plasma metabolites and bacterial diversity produced a strong correlation of metabolic alterations, such as reduced short-chain fatty acids and an increase in primary bile acids, with a differential abundance of distinct bacteria in HF. In conclusion, we showed that HF begets HF, likely via a vicious cycle of an altered microbiome and metabolic products.

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Project description:Label-free quantification of cardiac tissue following transverse aortic constriction (TAC) in a WT and ADAM15-/- mouse model.

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Transcription profiling of hearts from FVB male mice subjected to cardiac pressure overload by transverse aortic constriction to study the quantitative relationships between gene expression and left ventricular hypertrophy

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Project description:The purpose of the experiment is to assess the genes expression changes in the heart in response to transverse aortic constriction (TAC)-induced pressure overload, and to identify the genes which are involved in the pathogenesis of heart failure induced by hypertension; thereafter examining the individual gene function in the heart and discovering the novel drug targets to prevent heart failure. Wild-type C57 mice were subjected to transverse aortic constriction (TAC) for 12 weeks (sham as the control, Con). The hearts were collected and snap frozen for the following experiments.

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Transcription profiling of mouse gene expression after transverse aortic constriction in mice: comparison of TAC vs. sham group at 2, 10 and 21 days to identify the differential expression of genes

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