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Expt 6---Comprative transcriptomics of euploid and aneuploid Candida albicans strains

ABSTRACT: Expt 6---Comprative transcriptomics of euploid and aneuploid Candida albicans strains

PROVIDER: PRJEB56115 | ENA |

REPOSITORIES: ENA

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Expt 6---Comprative transcriptomics of euploid and aneuploid Candida albicans strains

Project description:Candida albicans lab strain SC5314, which is a euploid diploid, was used to generate aneuploid fluconazole adaptors. Transcriptomes of aneuploids were compared to the euploid parent by growing cells in rich YPD broth.

2022-09-26 | E-MTAB-12185 | biostudies-arrayexpress

Transcriptome analysis of aneuploid and euploid Candida albicans strains

Project description:We obtained ketoconazole tolerant mutants in Candida albicans after exposing the strain SC5314 to inhibitory concentration of ketoconazole. We did RNA-Seq to compare the transcriptomes of the aneuploid strains versus the parent euploid strain.

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Transcriptome analysis of aneuploid and euploid Candida albicans strains

Project description:Transcriptome analysis of aneuploid and euploid Candida albicans strains

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Comparative trancriptomes of aneuploid and euploid Candida glabrata strains

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A collection of Candida albicans aneuploid strains

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Transcriptomes of aneuploid Candida parapsilosis strains

Project description:In Candida parapsilosis, transcriptomes of two aneuploid adaptors, TJ60 and TJ74, were compared to the euploid parent #12108. Cells were grown in YPD broth at 37C from OD600=0.1 to 1.0. Cells were collected and RNA was extracted.

2023-08-11 | E-MTAB-12322 | biostudies-arrayexpress

A collection of Candida albicans aneuploid strains

Project description:We used C. albicans diploid reference strain SC5314 to obtain aneuploid colonies via selection by drugs. We got a collection of aneuploid strains bearing trisomy of each homolog of each chromosome.

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Whole genome sequencing of spontaneous revertants derived from aneuploid Candida albicans strains

Project description:In Candida albicans, aneuploids are unstable. When grown on YPD-agar plates, aneuploids exhibit colony size variations. In this study, 6 aneuploid strains were spread on YPD-agar plates. The large colonies from each strain were sequenced. The small colonies were sequenced in another project.

2023-05-05 | E-MTAB-12409 | biostudies-arrayexpress

CGH analysis of Candida albicans strains

Project description:Aneuploidy and the evolution of aneuploid karyotypes of Candida albicans strains was identified using aCGH. Whole chromosome and segmental aneuploidies, (specifically on the left arm of chromosome 5 - shown to be due to isochromosome formation) are associated with the appearance of resistance to the antifungal drug fluconazole. Keywords: Comparative Genomic Hybridization

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Transcriptome analysis of aneuploid tebuconazole adaptors in Candida albicans

Project description:Candida albicans lab strain SC5314 was used as parent to obtain tebuconazole adaptors. Two adaptors, TJ1503 and TJ1669 were aneuploid. Transcriptomes of these two strains were compared to SC5314.

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