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Cultured resident and thioglycolate-elicited mouse peritoneal macrophages

ABSTRACT: Cultured resident and thioglycolate-elicited mouse peritoneal macrophages

PROVIDER: PRJNA667718 | ENA |

REPOSITORIES: ENA

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Cultured resident and thioglycolate-elicited mouse peritoneal macrophages

Project description:In macrophage biology, resident peritoneal macrophages (RPMs) and thioglycolate-elicited peritoneal macrophages (TGPMs) have been traditionally utilized as primary cultured models. RPMs and TGPMs display distinct morphological and functional characteristics. We analyzed altered gene expression between RPMs from control mice and TGPMs from thioglycolate-injected mice.

2020-10-07 | GSE159119 | GEO

Expression data from wild type and Gata6-deficient tissue resident peritoneal macrophages

Project description:Tissue resident macrophages are notoriously heterogeneous, exhibiting discrete phenotypes as a consequence of tissue- and micro-anatomical niche-specific functions, but the molecular basis for this is not understood. We resolved a restricted transcriptional profile for the self-renewing population of peritoneal resident macrophages, which is expressed during homeostasis and inflammation and distinct from other MM-CM-^X. Prominent within this profile was the expression of Gata6. This study represents a characterisation of the role of Gata6 in peritoneal resident macrophage phenotype. We used microarrays to determine the patterns of gene expression in peritoneal resident MM-CM-^X in the absence of GATA-6 against wild type. Conditional 'floxed' Gata6 deficient sex-matched mice between 7 weeks old were compared against wild type

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microRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages

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2014-05-09 | GSE47049 | GEO

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Project description:RNA transcriptome data from C57BL/6 tissue resident peritoneal macrophages over expressing microRNA 708 or control. The role of microRNA-708 in shaping macrophage biology remains mostly unknown. Here, using lentiviral vectors we overexpressed microRNA-708 in vivo in C57BL/6 mice peritoneal macrophages and investigated mRNA changes in these cells after 4 days.

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Resident peritoneal macrophage exhibit marked sexual dimorphism in gene expression

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Project description:Here we study the effect of LPS in the transcriptome of thioglycollate-elicited peritoneal macrophages isolated from Ldlr knock out mice

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Expression data of peritoneal macrophages from Wild-type mouse cultured in control or serine/glycine-depleted medium.

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Project description:Here we study the effect of LPS in the transcriptome of thioglycollate-elicited peritoneal macrophages isolated from Ldlr knock out and Ch25h;Ldlr double knock out mice

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