Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Systems biology approaches reveal low-dose effects of nanoparticles

ABSTRACT: Systems biology approaches reveal low-dose effects of nanoparticles

OTHER RELATED OMICS DATASETS IN: E-MTAB-2397

PROVIDER: PRJEB8224 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR732447.fastq.gz	Fastqsanger.gz
	ERR732448.fastq.gz	Fastqsanger.gz
	ERR732449.fastq.gz	Fastqsanger.gz
	ERR732450.fastq.gz	Fastqsanger.gz
	ERR732451.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Systems biology approaches reveal low-dose effects of nanoparticles

Project description:Here, we show that systems biology approaches can uncover mechanisms underlying cellular responses to nanomaterials. Using RNA Seq, we found that cationic nanoparticles are capable of triggering down-regulation of cell cycle-related genes in primary human bronchial epithelial cells at doses that do not elicit acute cytotoxicity. Bioinformatics analyses implicated NF-kappaB as a putative transcriptional regulator and functional assays confirmed that cationic nanoparticles caused NF-kappaB-dependent cell cycle arrest. Our study demonstrates the feasibility of applying systems biology tools to assess cellular responses to nanomaterials, not least at low doses.

2015-01-17 | E-MTAB-2397 | biostudies-arrayexpress

E-MTAB-2397

Project description:Systems biology approaches reveal low-dose effects of nanoparticles

2019-05-14 | E-MTAB-2397 | ExpressionAtlas

Defining clinical and sterile immunity to Plasmodium falciparum infection using systems biology approaches

Project description:Defining clinical and sterile immunity to Plasmodium falciparum infection using systems biology approaches

| PRJNA685232 | ENA

Using Systems Biology Approaches to Identify Signaling Pathways Activated During Chronic Wound Initiation

Project description:Using Systems Biology Approaches to Identify Signaling Pathways Activated During Chronic Wound Initiation

| PRJNA760434 | ENA

Systems biology of prostate cancer

Project description:Systems biology of prostate cancer

| PRJEB34826 | ENA

Genetic Endothelial Systems Biology of Sickle Stroke Risk

Project description:Genetic differences in endothelial biology could underlie development of phenotypic heterogeneity amongst individuals afflicted with vascular diseases. We obtained BOEC (blood outgrowth endothelial cells) from 20 subjects with sickle cell anemia (age 4-19) shown to be either at-risk (n=11) or not-at-risk (n=9) for ischemic stroke due to, respectively, having or not having occlusive disease at the Circle of Willis (CoW). Gene expression profiling identified no significant single gene differences between the two groups, as expected. However, analysis of Biological Systems Scores, using gene sets that were pre-determined to survey each of nine biological systems, showed that only changes in inflammation signaling are characteristic of the at-risk subjects, as supported by multiple statistical approaches Keywords: disease status analysis

2007-12-18 | GSE9877 | GEO

Elucidating transcriptional regulation of nitrogen metabolism with systems approaches

Project description:Elucidating transcriptional regulation of nitrogen metabolism with systems approaches

| PRJNA238009 | ENA

Integrated systems-biology platform for power-to-gas technology

Project description:Integrated systems-biology platform for power-to-gas technology

| PRJNA902403 | ENA

Systems biology of vaccination for seasonal influenza in humans

Project description:Systems biology of vaccination for seasonal influenza in humans

| PRJNA141363 | ENA

Low and High Dose Progestins Elicit Distinct Breast Cancer Biology

Project description:An incomplete understanding of dose-dependent progesterone receptor (PR) biology has led to the suboptimal exploitation of PR as a therapeutic target. While hormone replacement therapies (HRT) containing low-doses of synthetic progestogens (progestins) have been associated with an increased risk of breast cancer, high-dose progestin therapies have beneficial therapeutic effects in some patients with breast cancer. Herein we report that PR subcellular localization, post-trans3lational modifications, stability, chromatin binding, responsive gene expression and downstream biology differ considerably as a function of progestin concentration. Dose-dependent transcriptional profiling revealed that different concentrations of progestin elicit classic sigmoidal and/or biphasic gene induction at distinct target gene sets. Notably, when compared to high doses of progestin, low-dose treatments lead to minimal nuclear translocation of PR while supporting robust induction of a subset of target genes, indicating that PR occupancy has a complex relationship to target gene induction. Interestingly, high but not low-dose progestin treatments lead to increased phosphorylation at Ser294 and is associated with higher receptor turnover. Furthermore, while low-dose treatments stimulate cell proliferation, high-dose treatments do not result in significant cell cycle progression to S phase. Similar biphasic and sigmoidal patterns of gene induction were observed in human breast tumor explants treated with various concentrations of progestin, underscoring the need to fine tune the dosage of PR-targeting therapies. Given the wide range of medical applications of PR target therapy, our discovery of distinct dose-dependent PR biology may have important clinical implications.

2020-06-13 | GSE99986 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data