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Systems biology approaches reveal low-dose effects of nanoparticles

ABSTRACT: Systems biology approaches reveal low-dose effects of nanoparticles

OTHER RELATED OMICS DATASETS IN: E-MTAB-2397

PROVIDER: PRJEB8224 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR732447.fastq.gz	Fastqsanger.gz
	ERR732448.fastq.gz	Fastqsanger.gz
	ERR732449.fastq.gz	Fastqsanger.gz
	ERR732450.fastq.gz	Fastqsanger.gz
	ERR732451.fastq.gz	Fastqsanger.gz

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Systems biology approaches reveal low-dose effects of nanoparticles

Project description:Here, we show that systems biology approaches can uncover mechanisms underlying cellular responses to nanomaterials. Using RNA Seq, we found that cationic nanoparticles are capable of triggering down-regulation of cell cycle-related genes in primary human bronchial epithelial cells at doses that do not elicit acute cytotoxicity. Bioinformatics analyses implicated NF-kappaB as a putative transcriptional regulator and functional assays confirmed that cationic nanoparticles caused NF-kappaB-dependent cell cycle arrest. Our study demonstrates the feasibility of applying systems biology tools to assess cellular responses to nanomaterials, not least at low doses.

2015-01-17 | E-MTAB-2397 | biostudies-arrayexpress

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