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SOX4 promotes T cell acute lymphoblastic leukemia progression

ABSTRACT: SOX4 promotes T cell acute lymphoblastic leukemia progression

PROVIDER: PRJNA1052077 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27200488_1.fastq.gz	Fastqsanger.gz
	SRR27200488_2.fastq.gz	Fastqsanger.gz
	SRR27200489_1.fastq.gz	Fastqsanger.gz
	SRR27200489_2.fastq.gz	Fastqsanger.gz
	SRR27200490_1.fastq.gz	Fastqsanger.gz

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SOX4 promotes T cell acute lymphoblastic leukemia progression

Project description:We report a previously unrecognized role of SOX4 in T cell acute lymphoblastic leukemia (T-ALL). To explore SOX4-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the SOX4-knockdown Jurkat cells in comparison to control group.

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Project description:Mutation or epigenetic silencing of the transcription factor C/EBPa is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but down-stream targets relevant for leukemogenesis are not known. Here we identify Sox4 as a direct target of C/EBPa whereby its expression is inversely correlated with C/EBPa activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored their differentiation. Gene expression profiles of leukemia initiating cells (LICs) from both Sox4 overexpression and murine mutant C/EBPa AML models clustered together, but differed from other types of AML. Our data demonstrate that Sox4 overexpression resulting from C/EBPa inactivation contributes to the development of leukemias with a distinct LIC phenotype. A ChIP-seq sample of C/EBPa in Macrophages is used in this study

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