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Gallus gallus

ABSTRACT: Transcriptome analysis reveals an activation of MHC-I and MHC-II pathways in chicken trachea immunized with infectious laryngotracheitis virus vaccine

PROVIDER: PRJNA197130 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR826892.fastq.gz	Fastqsanger.gz
	SRR826893.fastq.gz	Fastqsanger.gz
	SRR826894.fastq.gz	Fastqsanger.gz

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Similar Datasets

Transcriptome analysis reveals an activation of MHC-I and MHC-II pathways in chicken trachea immunized with infectious laryngotracheitis virus vaccine

Project description:Infectious laryngotracheitis (ILT) is an acute, contagious, upper respiratory disease, which is caused by gallid herpesvirus 1 (GaHV-1). Due to the mortality rates up to 70% depending on the virulence of the virus, it is of economic importance of the disease to explore the etiology of the ILT in the poultry industry. In this study, 15-day-old SPF white leghorn chickens were used to transcriptome analysis in chicken trachea immunized with infectious laryngotracheitis virus vaccine. In conclusion, chicken embryo origin (CEO) vaccine activation of the MHC-I and MHC-II pathways provides insight into the molecular mechanism of immune response in chickens, and holds potential for evaluation and design of new ILT vaccines in a manner adapted to the host immune response to the virus.

2014-04-08 | GSE46046 | GEO

Transcriptome analysis reveals an activation of MHC-I and MHC-II pathways in chicken trachea immunized with infectious laryngotracheitis virus vaccine

2014-04-08 | E-GEOD-46046 | biostudies-arrayexpress

Gallus gallus

Project description:Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine

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An integrated transcriptome analysis to the characterization of host responses against infectious laryngostracheitis virus vaccine infection in chicken embryo lung cells

2011-06-29 | GSE30269 | GEO

An integrated transcriptome analysis to the characterization of host responses against infectious laryngostracheitis virus vaccine infection in chicken embryo lung cells

Project description:Host gene expression of chicken embryo lung cells infected an infectious laryngotracheitis virus (ILTV) vaccine strain comparing control uninfected lung cells. Goal was to identify the changes of host gene expression by ILTV vaccine infection. Two-condition experiment, uninfected chicken embryo lung cells vs. vaccine infected chicken embryo lung cells. Biological replicates: 1 control uninfected sample, 1 vaccinal ILTV infected experimental sample at each 1, 2, 3 and 4 dpi.

2011-06-29 | E-GEOD-30269 | biostudies-arrayexpress

Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine

Project description:In this study we investigated the methylome of chickens immunized with Infectious laryngotracheitis (ILT) vaccine derived from chicken embryos. Methyl-CpG binding domain protein-enriched genome sequencing (MBD-Seq) method was employed in the detection of the 1,155 differentially methylated regions (DMRs) across the entire genome. After validation, we ascertained the genomic DMRs distribution and annotated them regarding genes, transcription start sites (TSS) and CpG islands. We found that global DNA methylation decreased in vaccinated birds, presenting 704 hypomethylated and 451 hypermethylated DMRs, respectively. Additionally, we performed an enrichment analysis detecting gene networks, in which cancer and RNA post-transcriptional modification appeared in the first place, followed by humoral immune response, immunological disease and inflammatory disease. The top four identified canonical pathways were EIF2 signaling, regulation of EIF4 and p70S6K signaling, axonal guidance signaling and mTOR signaling, providing new insight regarding the mechanisms of ILT etiology. Lastly, the association between DNA methylation and differentially expressed genes was examined, and detected negative correlation in seventeen of the eighteen genes. DNA methylation analysis employing MBD-Seq with 3 salt concentrations, in vaccinated and control group of chickens with 2 biological replications

2014-08-28 | E-GEOD-56984 | biostudies-arrayexpress

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Project description:Development of gene expression signatures for chicken LMH cells infected with infectious laryngotracheitis virus (ILTV)

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Transcriptional Profiling of Host Gene Expression in Chicken Embryo Lung Cells Infected with Laryngotracheitis Virus

Project description:Transcriptional profiling of chicken embryo lung cells infected infectious laryngotracheitis virus (ILTV) comparing control uninfected lung cells. Goal was to determine the changes of host gene expression by ILTV infection and host-virus interaction.

2010-03-11 | GSE20630 | GEO

Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine

2014-08-28 | GSE56984 | GEO

Existence of conventional dendritic cells in Gallus gallus revealed by comparative gene expression profiling

Project description:The existence of conventional dendritic cells (cDCs) has not yet been demonstrated outside mammals. In this paper, we identified bona fide cDCs in chicken spleen. Comparative profiling of global and of immune response gene expression, morphology, and T cell activation properties show that cDCs and macrophages (MPs) exist as distinct mononuclear phagocytes in chicken, resembling their human and mouse cell counterparts. Using computational analysis, core gene expression signatures for cDCs, MPs, T and B cells across chicken, human and mouse were established, which will facilitate the identification of these subsets in other vertebrates. Overall this study, by extending the newly uncovered cDC and MP paradigm to chicken, suggests that the generation of these two phagocyte lineages occurred before the reptile to mammal and bird transition in evolution. It opens avenues for the design of new vaccines and neutraceuticals that are mandatory for the sustained supply of poultry products in the expanding human population. Four independent replicates of RNA from 4 cellular populations have been purified from histocompatible chicken spleens, based on surface markers and fluorecence cell sorting: putative conventional Dendritic cells (F2+, MHC-II+ cells) ; control B cells (BU-1+ cells; only 3 replicates could be included in the study); T cells (CD3+ cells) and macrophage spleen population (MHC-II+, KUL-01+ cells).

2014-05-01 | E-GEOD-55642 | biostudies-arrayexpress

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