Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: E2F1 transcription factor knockdown effect on gene expression in LNCaP-abl cells

PROVIDER: PRJNA242934 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1207244.fastq.gz	Fastqsanger.gz
	SRR1207245.fastq.gz	Fastqsanger.gz
	SRR1207246.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

Effects of Cardiac Glycosides on RNA Expression in Prostate Cancer LNCaP-abl Cells

Project description:Prostate cancer is the most common cancer in men and cardiac glycosides inhibit prostate cancer cell proliferation. In order to investigate the mechanism by which cardiac glycosides inhibit prostate cancer cells, we observed genome-wide RNA expression in prostate cancer LNCaP-abl cells, hormone resistant cells, after the cardiac glycoside treatment using RNA-Seq. In addition, we profiled LNCaP-abl cells after androgen receptor (AR) knockdown to observe whether cardiac glycoside effect on RNA expression is similar to that of AR knockdown. Observation of three cardioglycosides, Digoxin, Peruvoside and Strophanthidin, and AR knockdown regulated RNA expression in LNCaP-abl with RNA-Seq (each triplicates)

2012-04-03 | E-GEOD-35126 | biostudies-arrayexpress

Effects of Cardiac Glycosides on RNA Expression in Prostate Cancer LNCaP-abl Cells

2012-04-04 | GSE35126 | GEO

Genome-wide chromatin binding of transcription factor E2F1 in castration resistant prostate cancer (CRPC) cells

Project description:Our computational approach identified E2F1 as a collaborative factor for EZH2 in transcriptional regulation of cancer-related genes. This experiment is designed to validate the interaction between E2F1 and EZH2 on the chromatin. By obtaining over 1 billion bases of sequence from chromatin immunoprecipitated DNA, we generated the genome-wide localizations of E2F1 in CRPC cell line LNCaP-abl cells, and found that Indeed, these sites are enriched near the transcription start sites of EZH2-activated genes. Further analysis of the transcription factor motifs enriched at these peaks revealed the enrichement of androgen receptor motif, suggesting a co-activator role for EZH2 in concert with AR. Our work demonstrated a novel funtion of EZH2 in transcriptional activation by directly binding to the chromatin sites that cooperate with AR. Study of the chromatin localizations of PRC2 complex core subunits and different histone marks in 2 cell types

2015-04-14 | E-GEOD-67809 | biostudies-arrayexpress

Genome-wide chromatin binding of transcription factor E2F1 in castration resistant prostate cancer (CRPC) cells

2015-04-14 | GSE67809 | GEO

Homo sapiens

Project description:Expression data from LNCaP and abl cells

| PRJNA106451 | ENA

Homo sapiens

Project description:Expression data of treated LNCaP-abl cells

| PRJNA163627 | ENA

Homo sapiens

Project description:The effect of knockdown Abl kinases on breast cancer cells' global transcriptome

| PRJNA284608 | ENA