Project description:Expression changes in testes of 5 week old mice after knockout of Phf13 were analyzed using Affymetrix mouse genome 430 2.0 expression microarrays. Transcripts on the X- and Y-chromosome were significantly upregulated.
Project description:Expression changes in testes of 15-20 week old mice after knockout of Phf13 were analyzed using Affymetrix mouse genome 430 2.0 expression microarrays. Transcripts on the X- and Y-chromosome were significantly upregulated.
Project description:In the terminal end of the seminiferous tubules adjacent to rete testis (RT), there are valve-like structures called Sertoli valve (SV) epithelia. SV epithelia are constitutively missing most spermatogenesis activity partially through high GDNF expression, leading to the SV-specific enrichment of undifferentiated spermatogonia. We used microarrays to elucidate the molecular characterization in the SV epithelia.
Project description:Prkar1a encodes the regulatory subunit R1a of the proteine kinase A. Prkar1a ablation in the testis results in profound alterations of tissue homeostasis leading to tumor development and infertility. We used microarrays to analyze gene expression in response to Prkar1a gene ablation in testicular somatic cells (derived from SF1+ cells) (prKO model), in Sertoli cells (sKO model) or in Leydig cells (lrKO model) in 2-week and 2-month-old mouse testes.
Project description:To investigate the effect of youthful systemic milieu on acute kidney injury in a rat kidney transplantation model based on young (6-week-old) and adult (12-week-old) recipients receiving similar donor kidneys (12-week-old)