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Streptococcus pyogenes

ABSTRACT: RocA is an important regulator with serotype-specific pathogenesis activity in serotype M28 group A Streptococcus

PROVIDER: PRJNA470894 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7699120.fastq.gz	Fastqsanger.gz
	SRR7699121.fastq.gz	Fastqsanger.gz
	SRR7699122.fastq.gz	Fastqsanger.gz
	SRR7699123.fastq.gz	Fastqsanger.gz
	SRR7699124.fastq.gz	Fastqsanger.gz

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Polymorphisms in RocA contribute to the molecular pathogenesis of serotype M28 group A streptococcus

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Project description:Regulation of gene expression in serotype M1 group A Strep (GAS, aka S. pyogenes) by RocA

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Regulatory Rewiring Confers Serotype-Specific Hyper-Virulence in the Human Pathogen Group A Streptococcus

Project description:We sequenced mRNA transcripts from three isogenic M3 serotype GAS strains, parental (MGAS10870), complement (10870::rocAM1), and deletion (10870ΔrocA). There were no significant changes between the parental and revertant strain. Comparison of the parental and complemented strain revealed several virulence factors were up-regulated in the parental strain where RocA function was diminished. We concluded that RocA, through direct or indirect mechanisms, is able to control numerous virulence genes and this lack of RocA regulation increases expression of virulence factors, which contributes to the hyper-virulent state of serotype M3 GAS.

2015-08-24 | GSE68277 | GEO

Regulatory Rewiring Confers Serotype-Specific Hyper-Virulence in the Human Pathogen Group A Streptococcus

Project description:We sequenced mRNA transcripts from three isogenic M3 serotype GAS strains, parental (MGAS10870), complement (10870::rocAM1), and deletion (10870?rocA). There were no significant changes between the parental and revertant strain. Comparison of the parental and complemented strain revealed several virulence factors were up-regulated in the parental strain where RocA function was diminished. We concluded that RocA, through direct or indirect mechanisms, is able to control numerous virulence genes and this lack of RocA regulation increases expression of virulence factors, which contributes to the hyper-virulent state of serotype M3 GAS. GAS strains were grown to mid-exponential phase, total RNA isolated, rRNA depleted, cDNA libraries synthesized, and libraries analyzed using Illumina MiSeq and CLC Genomics Workbench version 7.5.1 RNA-seq software.

2015-08-24 | E-GEOD-68277 | biostudies-arrayexpress

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