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ChIP-Sequencing analysis of YY1 binding DNA in radiation-induced skin fibrosis of rats

ABSTRACT: ChIP-Sequencing analysis of YY1 binding DNA in radiation-induced skin fibrosis of rats

PROVIDER: PRJNA480036 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7479941_1.fastq.gz	Fastqsanger.gz
	SRR7479941_2.fastq.gz	Fastqsanger.gz
	SRR7479942_1.fastq.gz	Fastqsanger.gz
	SRR7479942_2.fastq.gz	Fastqsanger.gz
	SRR7479943_1.fastq.gz	Fastqsanger.gz

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ChIP-Sequencing analysis of YY1 binding DNA in radiation-induced skin fibrosis of rats

Project description:This study aims to compared the genome-wide Ying Yang-1 (YY1) binding DNA sequences in radiation-induced fibrotic skin and adjacent normal tissues of rats by ChIP-Seq. Male Sprague-Dawley (SD) rats (4 weeks old) were irradiated with a single 45-Gy dose of irradiation was administered to the treatment area at a rate of 750 cGy/min using a 6-MeV electron beam accelerator (Clinac 2100EX, Varian Medical Systems, Inc., CA). Skin tissues from nonirradated skin areas and irradietd areas were collected and subjected to ChIP of YY1.

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