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The in vitro influence of orexin B on the porcine myometrium on days 15 to 16 of gestation.

ABSTRACT: The in vitro influence of orexin B on the porcine myometrium on days 15 to 16 of gestation.

PROVIDER: PRJNA505072 | ENA |

REPOSITORIES: ENA

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The in vitro influence of orexin B on the porcine myometrium on days 15 to 16 of gestation.

Project description:Orexin A (OXA) and orexin B (OXB) are hypothalamic-derived peptides that participate in the regulation of energy metabolism, food intake and reproductive function by influencing the hypothalamic-pituitary-ovarian axis. Orexins are also produced in the endometrium, myometrium and placenta, which suggests that they could act as a link between energy metabolism and the reproductive system. The aim of this study was to explore the influence of orexin B on global gene expression in the porcine myometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-11-14 | GSE122414 | GEO

The in vitro influence of orexin A on the porcine endometrium on days 15 to 16 of gestation.

Project description:Orexin A belongs to the group of hypothalamic-derived peptides that are involved in a number of processes, such as regulation of energy metabolism, control of food intake and regulation of the reproductive system. Orexin A is also expressed in the endometrium, myometrium and placenta, which suggests that it may act as an important local regulator of the reproductive functions. The aim of this study was to explore the influence of orexin A on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-06-02 | GSE115195 | GEO

The in vitro influence of orexin B on the porcine endometrium on days 15 to 16 of gestation.

Project description:Orexins, namely orexin A (OXA) and orexin B (OXB) belongs to the family of neuropeptides produced mainly by specific neurons of the lateral region of the hypothalamus. Primarily orexins were recognized as hormones involved exclusively in the regulation of food intake and energy homeostasis. However, a growing body of evidences indicate their involvement in the regulation of an increasing number of biological processes, inter alia, in the regulation of the reproductive functions. The aim of this study was to explore the influence of orexin B on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-11-14 | GSE122415 | GEO

The in vitro effect of orexin A on the porcine myometrial transcriptomic profile during early-implantation period

Project description:Orexins belong to the group of metabolism regulating factors connected mainly with the nervous system. Both biologically active neuropeptides, orexin A (OXA) and orexin B (OXB) are products of the proteolytic cleavage of common 130 amino-acid precursor – prepro-orexin (PPO). In the reproductive system orexins has been found to act not only on the endocrine, but also auto- and paracrine manner. In the present study we focused on the effect of OXA treatment on the global gene expression in the porcine myometrium during the most dynamic phase of the early pregnancy – the implantation period (days 15 to 16 of gestation).

2018-11-09 | GSE122310 | GEO

The in vitro influence of adiponectin on the porcine myometrium on days 15 to 16 of gestation.

Project description:Adiponectin is secreted by the white adipose tissue and is one of the most important hormones that regulate metabolic homeostasis. The expression of adiponectin and adiponectin receptor genes and proteins in reproductive organs, such as the testes, ovaries and uterus, suggests that adiponectin is also involved in the regulation of reproductive functions. The aim of this study was to explore the influence of adiponectin on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-11-17 | GSE122642 | GEO

The in vitro influence of orexin B on the porcine endometrium on days 15 to 16 of gestation.

Project description:The in vitro influence of orexin B on the porcine endometrium on days 15 to 16 of gestation.

| PRJNA505073 | ENA

The in vitro influence of orexin A on the porcine endometrium on days 15 to 16 of gestation.

Project description:The in vitro influence of orexin A on the porcine endometrium on days 15 to 16 of gestation.

| PRJNA474094 | ENA

The in vitro influence of adiponectin on the porcine myometrium on days 15 to 16 of gestation.

Project description:The in vitro influence of adiponectin on the porcine myometrium on days 15 to 16 of gestation.

| PRJNA505834 | ENA

The in vitro influence of adiponectin on the porcine endometrium on days 15 to 16 of gestation.

Project description:Adiponectin is a hormone secreted primarily by white adipose tissue. Recent studies have shown that adiponectin and its receptors (AdipoR1 and AdipoR2) are expressed in different reproductive tissues, including the ovary and uterus. This newly discovered endocrine system plays an important role in the regulation of reproductive processes. The aim of this study was to explore the influence of adiponectin on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-11-14 | GSE122400 | GEO

Gene profiling within the orexin-producing neurons

Project description:Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and attacks of muscle atonia triggered by strong emotions (cataplexy). The best biological marker of narcolepsy is orexin deficiency with dramatic loss in hypothalamic orexin-producing neurons. Together with a tight HLA and T-cell receptor alpha(5) association, narcolepsy is believed to be autoimmune although all attempts to prove it have failed.To characterize orexin specific peptides we produced a transgenic mouse model to access to the orexin neurons transcription profile. We generated BAC-based transgenic mice by replacing the orexin coding sequence by a flag-tagged poly(A) binding protein (Pabp1) cDNA sequence. The basis of this construct is to take advantage of the ability of Pabp1 to bind to the poly(A) tails of mRNAs in vivo. Thus mRNAs from orexin cells are expected to be enriched by cross-linking them to the flag-tagged PABP and then co-immunoprecipitating this complex with a specific anti-flag monoclonal antibody. Keywords: cell type comparison

2010-02-15 | GSE17617 | GEO

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