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ABSTRACT: Effect of chronic alcohol consumption on lamina propria leukocytes

PROVIDER: PRJNA517728 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8503670.fastq.gz	Fastqsanger.gz
	SRR8503680.fastq.gz	Fastqsanger.gz
	SRR8503690.fastq.gz	Fastqsanger.gz
	SRR8503700.fastq.gz	Fastqsanger.gz
	SRR8503710.fastq.gz	Fastqsanger.gz

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Project description:We investigated the molecular mechanisms of chronic alcohol consumption or lipopolysaccharide insult by gene expression profiling in prefrontal cortex and liver of C57BL/6J mice. We identified similar patterns of transcriptional changes in brain and liver among three different alcohol consumption tests and lipopolysaccharide injection. We also demonstrated distinct genomic consequences of different types of alcohol consumption. The microarray experiment was performed to compare gene expression changes induced by three separate paradigms of alcohol consumption and immune activation by lipopolysaccharide injection. The three tests of alcohol consumption were the continuous chronic two bottle choice (Chronic), two bottle choice available every other day (Chronic Intermittent) and limited access to one bottle of ethanol (Drinking in the Dark). All alcohol studies utilized 20% ethanol and each treatment group had it's own control group which received only water. The immune activation test consisted of 2 lipopolysaccharide injections (1 mg/kg i.p.) spaced one week apart, with animals being sacrificed one week after the last injection. Control animals received saline injections. All studies used female, adult mice.

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