Ontology highlight
ABSTRACT:
PROVIDER: PRJNA540065 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Interventions: Case series:None
Primary outcome(s): exon genes;transcriptional expression;proteome;protein phosphorylation group
Study Design: Sequential
| 2739647 | ecrin-mdr-crc
Project description:Although cross-species transcriptional analysis has been generated for DCs37, transcriptomic conservation between mouse and human FRCs at single-cell resolution has been unclear. To test whether GREM1+ FRCs might also play a role in DC homeostasis in humans, we performed scRNA-seq of CD45–PDPN+ stromal cells, as well as CD45+CD11c+ immune cells from healthy human LNs of three donors.
| EGAS00001006211 | EGA
Project description:Cross-species gene expression analysis of species-specific differences in preclinical assessment of pharmaceutical compounds (human)
2015-07-15 | E-GEOD-47970 | ExpressionAtlas
Project description:Cross-species gene expression analysis of species-specific differences in preclinical assessment of pharmaceutical compounds (rat)
2015-07-16 | E-GEOD-47695 | ExpressionAtlas
Project description:Comparative analysis of two species of garlic seedlings: qualities and transcriptional landscape
| PRJNA797535 | ENA
Project description:Although cross-species transcriptional analysis has been generated for DCs, transcriptomic conservation between mouse and human FRCs at single-cell resolution has been unclear. To test whether GREM1+ FRCs might also play a role in DC homeostasis in humans, we performed scRNA-seq of CD45–PDPN+ stromal cells, as well as CD45+CD11c+ immune cells from healthy human LNs of three human donors. Data was generated using the 10x platform.
| EGAD00001008731 | EGA
Project description:The transcriptional regulatory structure of plant genomes remains poorly defined relative to that of animals. It has been unclear how many cis-regulatory elements generally exist in plant genomes, where these elements lie in relation to their target promoters, and how these features are conserved across species. We employed the Assay for Transposase-Accessible Chromatin with sequencing (ATAC-seq) in four different plant species (Arabidopsis thaliana, Medicago truncatula, Solanum lycopersicum, and Oryza sativa) to delineate open chromatin regions and transcription factor (TF) binding sites across each genome. Despite a ~10-fold variation in intergenic space among species, the majority of open chromatin regions consistently lie within 3 kb upstream of a transcription start site (TSS) in all four species. Nearly 70% of genes in Arabidopsis, Medicago, and Rice have a single putative regulatory region upstream of the TSS, while a similar percentage of tomato genes have 2-5 such elements. Despite variation in the location and number of regulatory elements within orthologous gene sets, transcriptional regulatory networks appear to be largely conserved across species. Profiling of open chromatin in the Arabidopsis root hair and non-hair epidermal cell types indicated that while the open chromatin landscapes of these two cell types were largely indistinguishable on a global scale, thousands of relatively subtle, quantitative cell-specific differences could be found. Analysis of TF binding sites in these differentially accessible regions led to the discovery of a MYB-driven transcriptional regulatory module unique to the hair cell type, which appears to control both hair cell fate regulators and abiotic stress responses. Our cross-species and cross-cell type analyses revealed common transcriptional regulatory principles among species and shed light on the mechanisms that produce cell type-specific transcriptomes during development.
2017-07-26 | GSE101482 | GEO