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Hippocampal gene expression profiling in mice treated with stigmasterol

ABSTRACT: Hippocampal gene expression profiling in mice treated with stigmasterol

PROVIDER: PRJNA555411 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9701630.fastq.gz	Fastqsanger.gz
	SRR9701631.fastq.gz	Fastqsanger.gz
	SRR9701632.fastq.gz	Fastqsanger.gz
	SRR9701633.fastq.gz	Fastqsanger.gz
	SRR9701624.fastq.gz	Fastqsanger.gz

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Hippocampal gene expression profiling in mice treated with stigmasterol

Project description:Anxiety and stress-related conditions represent a significant health burden in modern society. Unfortunately, most of the drugs currently used in the clinic modulate neurotransmission and are prone to side effects, limiting their long-term use. We used bioinformatics screening to find small molecules mimicking the transcriptional profile recently reported in hippocampi of importin α5 mutant anxiolytic mice, identifying the plant sterol β-sitosterol as a top candidate. Behavioral analyses confirmed anxiolytic properties of β-sitosterol, but did not show anxiolytic activity for stigmasterol, a related plant sterol. The present RNA-seq experiment characterizes the hippocampal transcriptome in mice 1 hr and 6 hrs after after intraperitoneal injection of 100 mg/kg stigmasterol or vehicle.

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