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ABSTRACT: Eucommia ulmoides leaf transcriptome

PROVIDER: PRJNA559770 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9949130_1.fastq.gz	Fastqsanger.gz
	SRR9949130_2.fastq.gz	Fastqsanger.gz
	SRR9949131_1.fastq.gz	Fastqsanger.gz
	SRR9949131_2.fastq.gz	Fastqsanger.gz
	SRR9949132_1.fastq.gz	Fastqsanger.gz

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Gene expression data from liver of rat fed a high-fat diet and high-fructose water without/with Eucommia ulmoides leaves

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Gene expression data from liver of rat fed a high-fat diet and high-fructose water without/with Eucommia ulmoides leaves

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Project description:The nematode Caenorhabditis elegans was treated with extracts of the Traditional Chinese Medicine plants Cuscuta chinensis and Eucommia ulmoides from the L4 stage. In aged worms (on the 7th and 12th day of adulthood) different health parameters were determined. Besides the prolongation of lifespan, we found that C. chinensis improved the swimming behavior, pharyngeal pumping rate, stress resistance, mechanosensation and memory of aged C. elegans. Furthermore, the extract treatment reduced the autofluorescence, which is a known biomarker of ageing. Thus, we concluded that C. chinensis is an overall healthspan enhancer. In contrast, the E. ulmoides extract specifically enhanced the lifespan and stress resistance of aged C. elegans, but did not improve any other health aspect. To reveal the mechanism behind the healthspan enhancing effects of C. chinensis, the transcriptome of treated and untreated C. elegans on the 12th day of adulthood was analysed. For comparison purposes, E. ulmoides treated nematodes were included in the analysis.

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