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AP-1 and TGFb-dependent transcriptomic changes in resistant basal cell carcinoma cell line

ABSTRACT: AP-1 and TGFb-dependent transcriptomic changes in resistant basal cell carcinoma cell line

PROVIDER: PRJNA659018 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12508542_1.fastq.gz	Fastqsanger.gz
	SRR12508542_2.fastq.gz	Fastqsanger.gz
	SRR12508543_1.fastq.gz	Fastqsanger.gz
	SRR12508543_2.fastq.gz	Fastqsanger.gz
	SRR12508544_1.fastq.gz	Fastqsanger.gz

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AP-1 and TGFb-dependent transcriptomic changes in resistant basal cell carcinoma cell line

Project description:Tumor heterogeneity and lack of knowledge about resistant cell states remain a significant barrier to effective targeted cancer therapies. Basal cell carcinomas (BCCs) uniformly depend on Hedgehog (Hh)/Gli signaling for cell growth. We previously identified a nuclear myocardin-related transcription factor (nMRTF) resistance pathway that amplifies Gli1 activity, but nMRTF cell state and key factors driving its accumulation remain unknown. We have determined that AP-1 and TGFb transcription factor activity is essential to maintain MRTF activation. Here, we treat a murine BCC cell line with small molecule AP-1 and ALK5 inhibitors and analyze transcriptomic profiles.

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AP-1 and TGFb cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

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AP-1 dependent changes in chromatin accessibility in resistant basal cell carcinoma cell line

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AP-1 and TGFb cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-08-25 | GSE156855 | GEO

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