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Identification of miRNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis [miRNA]

ABSTRACT: Identification of miRNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis [miRNA]

PROVIDER: PRJNA664330 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12668778.fastq.gz	Fastqsanger.gz
	SRR12668779.fastq.gz	Fastqsanger.gz
	SRR12668780.fastq.gz	Fastqsanger.gz
	SRR12668781.fastq.gz	Fastqsanger.gz
	SRR12668782.fastq.gz	Fastqsanger.gz

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Identification of miRNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis [miRNA]

Project description:To systematically profile and characterize miRNA expression pattern in the lesion epicenter of spinal tissues after traumatic spinal cord injury (TSCI). We used RNA-Seq to profle the expression and regulation patterns of miRNAs of mice models after TSCI. A total of 155 miRNAs were identified in TSCI mice models to be differentially expressed.

2021-10-27 | GSE158194 | GEO

Single nucleus RNAseq of mouse astrocytes after traumatic spinal cord injury

Project description:We conducted snRNAseq of mouse astrocytes after traumatic spinal cord injury (SCI). These data reveal transcriptomic similarities and differences among astrocytes in healthy spinal cord and after spinal cord injury.

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Identification of noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis

Project description:To systematically profile and characterize the noncoding RNA (ncRNA) expression pattern in the lesion epicenter of spinal tissues after traumatic spinal cord injury (TSCI). We used RNA-Seq to profle the expression and regulation patterns of noncoding RNAs and mRNAs of mice models after TSCI. A total of 498 circRNAs and 1203 mRNAs were identified in TSCI mice models to be differentially expressed. noncoding RNAs might play important roles via the competing endogenous RNA regulation pattern after TSCI, further findings arising from this study will not only expand the understanding of potential ncRNA biomarkers but also help guide therapeutic strategies for TSCI.

2021-10-27 | GSE158193 | GEO

Circular RNA expression alteration in rats after traumatic spinal cord injury (SCI)

Project description:To determine whether the expression levels of circular RNAs were altered and lay a foundation for future work, we used high-throughput microarray analysis to screen circular RNAs expression patterns in the spinal cord of adult rats after traumatic spinal cord injury (SCI), finally to evaluate the potential rat models as a platform for the development of novel therapeutic targets for spinal cord injury in future clinical studies. Overall six rats at 3 days post-SCI in two groups were used to perform the microarray.

2018-05-15 | GSE114426 | GEO

Identification of miRNA and noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis

Project description:Identification of miRNA and noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis

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Differential Expression profiles of tRNA-Derived Small RNAs in Rats After Traumatic Spinal Cord Injury

Project description:The goals of this study are to screen differential expression profiles of tRNA-Derived small RNAs (tsRNAs) in rats after traumatic spinal cord injury (SCI) using next-generation sequencing and qRT-PCR.As a result, in rat spinal cord 1 day after contusion, totally 297 tsRNAs differentially expressed were identified. 155 tsRNAs were significantly differentially expressed: 91 were significantly up-regulated, while 64 were significantly down-regulated after SCI (folding change>1.5; P<0.05).Next, four tsRNAs were selected to be verified by qRT-PCR. Taken together,this study explored, for the first time, the significant alteration of tsRNA expression profiles after traumatic SCI in rats and offered deep insights into many possible treatment targets of SCI by regulating tsRNAs.

2020-01-24 | GSE133157 | GEO

miRNA expression in developmental spinal cord

Project description:This study compared the microRNA expression in mouse fetal spinal cord at day 13.5 and newborn mouse spinal cord.

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Identification of noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis

Project description:Identification of noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis

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Single nucleus RNAseq of mouse astrocytes after traumatic spinal cord injury

Project description:Single nucleus RNAseq of mouse astrocytes after traumatic spinal cord injury

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Proteomics analysis of zebrafish spinal cord regeneration following extracellular matrix manipulations

Project description:Label-free mass spectrometry-based quantitative proteomics was applied to a larval zebrafish spinal cord injury model, which allows axon regeneration and functional recovery within two days (days post lesion; dpl) after a spinal cord transection in 3 day-old larvae (dpf). Proteomic profiling was performed of the lesion site at 1 dpl in control animals and animals with pdgfrb+ cell-specific overexpression of either zebrafish chondoradherin (chad; chad-mCherry fusion), fibromodulin a (fmoda; fmoda-mCherry fusion), lumican (lum; lum-mCherry fusion) or prolargin (prelp; prelp-mCherry fusion).

2023-09-06 | PXD037605 | Pride

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