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Identification of miRNA and noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis

ABSTRACT: Identification of miRNA and noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis

PROVIDER: PRJNA664322 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12668835_1.fastq.gz	Fastqsanger.gz
	SRR12668835_2.fastq.gz	Fastqsanger.gz
	SRR12668836_1.fastq.gz	Fastqsanger.gz
	SRR12668836_2.fastq.gz	Fastqsanger.gz
	SRR12668837_1.fastq.gz	Fastqsanger.gz

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Identification of noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis

Project description:To systematically profile and characterize the noncoding RNA (ncRNA) expression pattern in the lesion epicenter of spinal tissues after traumatic spinal cord injury (TSCI). We used RNA-Seq to profle the expression and regulation patterns of noncoding RNAs and mRNAs of mice models after TSCI. A total of 498 circRNAs and 1203 mRNAs were identified in TSCI mice models to be differentially expressed. noncoding RNAs might play important roles via the competing endogenous RNA regulation pattern after TSCI, further findings arising from this study will not only expand the understanding of potential ncRNA biomarkers but also help guide therapeutic strategies for TSCI.

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Identification of miRNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis [miRNA]

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Identification of noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis

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Project description:The goals of this study are to screen differential expression profiles of tRNA-Derived small RNAs (tsRNAs) in rats after traumatic spinal cord injury (SCI) using next-generation sequencing and qRT-PCR.As a result, in rat spinal cord 1 day after contusion, totally 297 tsRNAs differentially expressed were identified. 155 tsRNAs were significantly differentially expressed: 91 were significantly up-regulated, while 64 were significantly down-regulated after SCI (folding change>1.5; P<0.05).Next, four tsRNAs were selected to be verified by qRT-PCR. Taken together,this study explored, for the first time, the significant alteration of tsRNA expression profiles after traumatic SCI in rats and offered deep insights into many possible treatment targets of SCI by regulating tsRNAs.

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