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RNA sequencing analysis of wild-type and Scd1-deficient CD4+ naïve T cells

ABSTRACT: RNA sequencing analysis of wild-type and Scd1-deficient CD4+ naïve T cells

PROVIDER: PRJNA671684 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12888603.fastq.gz	Fastqsanger.gz
	SRR12888604.fastq.gz	Fastqsanger.gz
	SRR12888605.fastq.gz	Fastqsanger.gz
	SRR12888606.fastq.gz	Fastqsanger.gz
	SRR12888607.fastq.gz	Fastqsanger.gz

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RNA sequencing analysis of wild-type and Scd1-deficient CD4+ naïve T cells

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Project description:We found that naïve T cells from SCD1-/- mice have an intrinsic preference for regulatory T cells differentiation. Such preference was imprinted to DN3 thymocytes developed in SCD1 deficient thymus and persisted to mature T cells. To investigate the potential epigenetic changes underlying the Treg-bias. We employed ATAC-seq to examine the chromatin accessibility of naïve T cells and DN3 thymocytes from SCD1-/- mice and their littermate controls.

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RNASeq Analysis of Gene Expression in Naïve and Regulatory CD4+ T cells from Wild Type and YAP-deficient mice

Project description:Regulatory T cells (Tregs) are critical for maintaining self-tolerance and immune homeostasis, but their suppressive function can impede effective anti-tumor immune responses. Foxp3 is a transcription factor expressed in Tregs that is required for their function. The pathways and microenvironmental cues governing Foxp3 expression and Treg function are not completely understood. We found that Yes-associated protein (YAP), a co-activator of the Hippo pathway, is highly expressed in Tregs and bolsters Foxp3 expression and Treg function in vitro and in vivo. To assess how YAP influences patterns of gene expression in Tregs, naïve CD4+ T cells and Tregs were isolated from wild type mice and CD4+ T cell lineage-restricted YAP knockout mice (YAPflox/flox, CD4-Cre+). Gene expression by naïve CD4+ T cells and their resting and stimulated Treg counterparts was analyzed by RNASeq. Our findings reveal that YAP ablation undermines expression of multiple genes involved in the TGFβ/SMAD signaling pathway in Tregs including Activin. These findings suggest that YAP potentiates activity along a pro-Treg signaling axis.

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