Project description:During development, the inherited DNA methylation patterns from the parental gametes needs to be remodeled into a state compatible with embryonic pluripotency. In Zebrafish, this remodeling is achieved by the maternal methylome becoming hypomethylated to match the paternal methylome. However, how this is achieved in medaka (another teleost fish) is currently not known. Moreover, how DNA methylation remodeling is impacted in hybrid organisms, and the effects this may have on their development, is also not known. Here we address these questions by generation whole genome bisulfite sequencing data for zebrafish, medaka and zebrafish medaka embryos.

2023-08-25 | E-MTAB-12535 | biostudies-arrayexpress

Whole Genome Bisulfite Sequencing (WGBS) or zebrafish, medaka, and zebrafish-medaka hybrid embryos

Project description:Whole Genome Bisulfite Sequencing (WGBS) or zebrafish, medaka, and zebrafish-medaka hybrid embryos

| PRJEB59047 | ENA

Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes

Project description:Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes

| PRJNA841973 | ENA

Whole-genome bisulfite sequencing analysis of Pten's function in regulating cardiomyocyte differentiation

Project description:We report the function of Pten in regulating the cardiomyocyte differentiation, and then we performed whole-genome bisulfite sequencing for the wild-type and Pten knockout embryoid bodies and cardiomyocytes to analyse the methylomes. The results showed a significant difference between wild-type and Pten knockout groups in methylomes, and we performed a series of experiments to study the function of Pten in cardiogenesis.

2021-07-09 | GSE160236 | GEO

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