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Transcriptome analysis of human induced liver cancer-forming cells (iLCCs) , HepG2 cells, Huh6 cells, Huh7 cells, and HuCCT1 cells

ABSTRACT: Transcriptome analysis of human induced liver cancer-forming cells (iLCCs) , HepG2 cells, Huh6 cells, Huh7 cells, and HuCCT1 cells

PROVIDER: PRJNA714879 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13977122.fastq.gz	Fastqsanger.gz
	SRR13977123.fastq.gz	Fastqsanger.gz
	SRR13977124.fastq.gz	Fastqsanger.gz
	SRR13977125.fastq.gz	Fastqsanger.gz
	SRR13977126.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of human induced liver cancer-forming cells (iLCCs) , HepG2 cells, Huh6 cells, Huh7 cells, and HuCCT1 cells

Project description:We found that a set of six transcription factors, FOXA3, HNF1A, HNF1B, LIN28B, L-MYC, and KLF5, can induce direct conversion of human umbilical vein endothelial cells (HUVECs) into liver cancer-forming cells (LCCs). These induced LCCs (iLCCs) efficiently arise tumors that closely resemble human combined hepatocellular cholangiocarcinoma after transplantation. We conducted 3' untranslated region (UTR)-seq (RNA-seq) analyses to investigate the characteristincs of iLCCs, HepG2 cells, Huh6 cells, Huh7 cells, and HuCCT1 cells.

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