Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

USP22 overexpression leads to aberrant signal transduction but is not sufficient to drive tumor formation in mice

ABSTRACT: USP22 overexpression leads to aberrant signal transduction but is not sufficient to drive tumor formation in mice

PROVIDER: PRJNA746259 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15120610_1.fastq.gz	Fastqsanger.gz
	SRR15120610_2.fastq.gz	Fastqsanger.gz
	SRR15120612_1.fastq.gz	Fastqsanger.gz
	SRR15120612_2.fastq.gz	Fastqsanger.gz
	SRR15120614_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 28

Similar Datasets

USP22 overexpression leads to aberrant signal transduction but is not sufficient to drive tumor formation in mice

Project description:USP22 overexpression is observed in several human cancers and is correlated with poor patient outcomes. The molecular basis underlying this correlation is not clear. USP22 is the catalytic subunit of the deubiquitylation module in the SAGA histone modifying complex, which regulates gene transcription. Our previous work demonstrated that loss of USP22 in mice leads to decreased expression of several components of receptor tyrosine kinase and TGFβ signaling pathways. To determine whether these pathways are upregulated when USP22 is overexpressed, we created a mouse model that expresses high levels of USP22 in all tissues. Phenotypic characterization of these mice revealed over branching of the mammary glands in females. Transcriptomic analyses indicate upregulation of key pathways involved in mammary gland branching in mammary epithelial cells derived from the USP22 overexpressing mice, including estrogen receptor, ERK/MAPK and TGFβ signaling. However, USP22 overexpression did not lead to increased tumorigenesis in any tissue. Our findings indicate that elevated levels of USP22 are not sufficient to induce tumors but it may enhance signaling abnormalities associated with oncogenesis.

2021-08-13 | GSE180005 | GEO

<i>Usp22</i> Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice.

Project description:Usp22 overexpression is observed in several human cancers and is correlated with poor patient outcomes. The molecular basis underlying this correlation is not clear. Usp22 is the catalytic subunit of the deubiquitylation module in the SAGA histone-modifying complex, which regulates gene transcription. Our previous work demonstrated that the loss of Usp22 in mice leads to decreased expression of several components of receptor tyrosine kinase and TGFβ signaling pathways. To determine whether these pathways are upregulated when Usp22 is overexpressed, we created a mouse model that expresses high levels of Usp22 in all tissues. Phenotypic characterization of these mice revealed over-branching of the mammary glands in females. Transcriptomic analyses indicate the upregulation of key pathways involved in mammary gland branching in mammary epithelial cells derived from the Usp22-overexpressing mice, including estrogen receptor, ERK/MAPK, and TGFβ signaling. However, Usp22 overexpression did not lead to increased tumorigenesis in any tissue. Our findings indicate that elevated levels of Usp22 are not sufficient to induce tumors, but it may enhance signaling abnormalities associated with oncogenesis.

| S-EPMC8428332 | biostudies-literature

Subcellular location defines GPCR signal transduction

Project description:Subcellular location defines GPCR signal transduction

| PRJNA915973 | ENA

RNAi of signal transduction components in HCT116 cells

Project description:RNAi of signal transduction components in HCT116 cells

| PRJEB2536 | ENA

RNAi of signal transduction components in Drosophila S2 cells

Project description:RNAi of signal transduction components in Drosophila S2 cells

| PRJEB2222 | ENA

Transcriptional profiling of Usp22-WT and Usp22-KO pancreatic tumor cells

Project description:RNA-seq analysis of sorted Usp22-WT and Usp22-KO tumor cells from subcutaneously implanted mouse pancreatic tumors

2019-11-08 | GSE140088 | GEO

Two-component signal transduction systems in Streptomyces and related organisms

Project description:Two-component signal transduction systems in Streptomyces and related organisms

| PRJNA110647 | ENA

Hydrogen modulates signal transduction through manipulating oxidized phospholipid mediators

Project description:We have previously demonstrated that molecular hydrogen (H2) neutralizes hydroxyl radical (•OH) in cultured-cells and protects cells and tissues against oxidative stress. Growing evidence has confirmed that H2-consumption exhibits preventive and therapeutic effects in patients with various diseases as well as model animals. Moreover, a small amount of H2 modulates signal transduction for regulating the expression of various genes; however, the primary target of H2 for exhibiting a variety of phenotypes was completely unknown. Here we show that H2 at low amounts manipulates oxidized phospholipid mediators to modulate Ca2+-signal transduction and gene expression.

2014-10-17 | GSE62434 | GEO

ACC-MESO1 cells: Control shRNA vs USP22 shRNA

Project description:USP22 plays oncogenic role and in order to study molecular mechanism of USP22 to promote tumorigenesis, microarray analysis was performed on USP22 knockdowned cells.

2018-10-01 | GSE104929 | GEO

Single-cell intracellular epitope and transcript detection revealing signal transduction dynamics

Project description:Single-cell intracellular epitope and transcript detection revealing signal transduction dynamics

| PRJNA681901 | ENA