Project description:Antigen-specific T cells are particularly important for eliminating bacterial infection, and the dynamics in this process help uncover the mechanisms by which bacteria are eliminated.This study used MHC class I tetramers to recognize the antigen OVA antigen-specific CD8+ T cells in mouse spleen and liver. Then combined the RNAseq and LC-MS/MS analysis to track the changes of the OVA antigen-specific CD8+ T cells at different time points (5 days,7 days, and 14 days post listeria infection).Transcriptomics coupled proteomics reveals the key signaling pathways to regulate antigen-specific CD8+ T cells by infection of Listeria monocytogenes expressing the OVA protein in mouse spleen and liver.

2024-03-26 | PXD050970 |

Transcriptomics of liver and PBMCs in alcohol-associated liver disease

Project description:Transcriptomics of liver and PBMCs in alcohol-associated liver disease

| PRJNA899977 | ENA

Transcriptomics of liver and PBMCs in alcohol-associated liver disease

Project description:Transcriptomics of liver and PBMCs in alcohol-associated liver disease

| PRJNA899978 | ENA

Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis

Project description:We profile the transcriptomes of ~30,000 mouse single cells to deconvolve the hepatic mesenchyme in healthy and fibrotic liver at high resolution. We reveal spatial zonation of hepatic stellate cells across the liver lobule, designated portal vein-associated HSC and central vein-associated HSC, and uncover an equivalent functional zonation in a mouse model of centrilobular fibrosis. Our work illustrates the power of single-cell transcriptomics to resolve key collagen-producing cells driving liver fibrosis with high precision.

2019-11-01 | GSE137720 | GEO

Transcriptomics analysis of gene expression in wildtype and foxo1 synonymous mutated mouse liver

Project description:Transcriptomics analysis of gene expression in wildtype and foxo1 synonymous mutated mouse liver

| PRJNA517499 | ENA