Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

ABSTRACT: RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

PROVIDER: PRJNA763899 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15914704.fastq.gz	Fastqsanger.gz
	SRR15914705.fastq.gz	Fastqsanger.gz
	SRR15914706.fastq.gz	Fastqsanger.gz
	SRR15914707.fastq.gz	Fastqsanger.gz
	SRR15914708.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 149

Similar Datasets

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

Project description:Here we analyze the transcriptional profiles of homogenized lungs resected from APOE2, APOE3, and APOE4 knock-in mice on day 4 post infection with SARS-CoV-2 MA10. This experiment validated a prior RNA-seq experiment revealing blunted adaptive immunity in APOE2 and APOE4 mice during COVID-19 progression.

2022-08-07 | GSE184288 | GEO

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

Project description:Here we analyze the transcriptional profiles of homogenized lungs resected from young female APOE2, APOE3, and APOE4 knock-in mice on day 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression.

2022-08-07 | GSE200132 | GEO

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

Project description:Here we analyze the transcriptional profiles of homogenized lungs resected from APOE2, APOE3, and APOE4 knock-in mice in the absence of infection (day 0) and on days 2 and 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression.

2022-08-07 | GSE184287 | GEO

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

Project description:RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

| PRJNA763901 | ENA

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

Project description:RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

| PRJNA823044 | ENA

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

Project description:RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

| PRJNA763900 | ENA

scRNAseq of lungs from APOE knock-in mice with COVID-19

Project description:scRNAseq of lungs from APOE knock-in mice with COVID-19

| PRJNA820450 | ENA

scRNAseq of lungs from APOE knock-in mice with COVID-19

Project description:We performed single cell RNA-sequencing of lungs from APOE knock-in mice in the absence of infection or four days post infection with SARS-CoV-2 MA10. Infected mice showed major remodeling of the cellular composition with expansion of myeloid cells and relative depletion of epithelial cells. In infected mice, APOE2 mice showed enrichment of pathways implicated in immune activation, consistent with immunologic misfiring.

2022-08-07 | GSE199498 | GEO

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-07 | GSE184289 | GEO

Two distinct immunopathological profiles in lungs of lethal COVID-19

Project description:Immune responses in lungs of Coronavirus Disease 2019 (COVID-19) are poorly characterized. We conducted transcriptomic, histologic and cellular profiling of post mortem COVID-19 and normal lung tissues. Two distinct immunopathological reaction patterns were identified. One pattern showed high expression of interferon stimulated genes (ISGs) and cytokines, high viral loads and limited pulmonary damage, the other pattern showed severely damaged lungs, low ISGs, low viral loads and abundant immune infiltrates. Distinct patterns of pulmonary COVID-19 immune responses correlated to hospitalization time and may guide treatment and vaccination approaches.

2020-09-02 | GSE151764 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data