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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

ABSTRACT: RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

PROVIDER: PRJNA823044 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18600735.fastq.gz	Fastqsanger.gz
	SRR18600736.fastq.gz	Fastqsanger.gz
	SRR18600737.fastq.gz	Fastqsanger.gz
	SRR18600738.fastq.gz	Fastqsanger.gz
	SRR18600739.fastq.gz	Fastqsanger.gz

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

Project description:Here we analyze the transcriptional profiles of homogenized lungs resected from young female APOE2, APOE3, and APOE4 knock-in mice on day 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression.

2022-08-07 | GSE200132 | GEO

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

Project description:Here we analyze the transcriptional profiles of homogenized lungs resected from APOE2, APOE3, and APOE4 knock-in mice on day 4 post infection with SARS-CoV-2 MA10. This experiment validated a prior RNA-seq experiment revealing blunted adaptive immunity in APOE2 and APOE4 mice during COVID-19 progression.

2022-08-07 | GSE184288 | GEO

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

Project description:RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

| PRJNA763899 | ENA

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

Project description:Here we analyze the transcriptional profiles of homogenized lungs resected from APOE2, APOE3, and APOE4 knock-in mice in the absence of infection (day 0) and on days 2 and 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression.

2022-08-07 | GSE184287 | GEO

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

Project description:RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

| PRJNA763900 | ENA

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

Project description:RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

| PRJNA763901 | ENA

scRNAseq of lungs from APOE knock-in mice with COVID-19

Project description:We performed single cell RNA-sequencing of lungs from APOE knock-in mice in the absence of infection or four days post infection with SARS-CoV-2 MA10. Infected mice showed major remodeling of the cellular composition with expansion of myeloid cells and relative depletion of epithelial cells. In infected mice, APOE2 mice showed enrichment of pathways implicated in immune activation, consistent with immunologic misfiring.

2022-08-07 | GSE199498 | GEO

scRNAseq of lungs from APOE knock-in mice with COVID-19

Project description:scRNAseq of lungs from APOE knock-in mice with COVID-19

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-07 | GSE184289 | GEO

ApoE determines the metabolic fate of apoC-III

Project description:Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased cardiovascular disease risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We recently established that in vivo apoC-III predominantly inhibits LDLR and LRP1 mediated hepatic TRL clearance and that apoC-III enriched TRLs are preferentially cleared by syndecan-1 (SDC1). In this study, we determined the impact of apoE, a common ligand for all three receptors, on apoC-III metabolism using apoC-III antisense oligonucleotide (ASO) treatment in mice lacking apoE and functional SDC1 (Apoe(-/-) Ndst1(f/f) Alb-Cre+). ApoC-III ASO treatment significantly reduced plasma TG levels in Apoe(-/-) Ndst1(f/f) Alb-Cre+ mice without reducing hepatic VLDL production or improving hepatic TRL clearance. Further analysis revealed that apoC-III ASO treatment lowered plasma TGs in Apoe(-/-) Ndst1(f/f) Alb-Cre+ mice, which was associated with increased LPL activity in white adipose tissue (WAT) in the fed state. Finally, clinical data confirm that ASO-mediated lowering of apoC-III via volanesorsen can reduce plasma TG levels independent of the apoE isoform genotype. Our data indicate that apoE determines the metabolic impact of apoC-III as we establish that apoE is essential to mediate inhibition of TRL clearance by apoC-III and that in the absence of functional apoE apoC-III inhibits tissue LPL activity.

2019-05-24 | GSE131284 | GEO

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