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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

ABSTRACT: RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

PROVIDER: PRJNA763901 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15914813.fastq.gz	Fastqsanger.gz
	SRR15914814.fastq.gz	Fastqsanger.gz
	SRR15914815.fastq.gz	Fastqsanger.gz
	SRR15914816.fastq.gz	Fastqsanger.gz
	SRR15914817.fastq.gz	Fastqsanger.gz

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

Project description:Here we analyze the transcriptional profiles of homogenized lungs resected from APOE2, APOE3, and APOE4 knock-in mice on day 4 post infection with SARS-CoV-2 MA10. This experiment validated a prior RNA-seq experiment revealing blunted adaptive immunity in APOE2 and APOE4 mice during COVID-19 progression.

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

Project description:Here we analyze the transcriptional profiles of homogenized lungs resected from young female APOE2, APOE3, and APOE4 knock-in mice on day 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression.

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

Project description:RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

Project description:Here we analyze the transcriptional profiles of homogenized lungs resected from APOE2, APOE3, and APOE4 knock-in mice in the absence of infection (day 0) and on days 2 and 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression.

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

Project description:RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

Project description:RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

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scRNAseq of lungs from APOE knock-in mice with COVID-19

Project description:scRNAseq of lungs from APOE knock-in mice with COVID-19

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scRNAseq of lungs from APOE knock-in mice with COVID-19

Project description:We performed single cell RNA-sequencing of lungs from APOE knock-in mice in the absence of infection or four days post infection with SARS-CoV-2 MA10. Infected mice showed major remodeling of the cellular composition with expansion of myeloid cells and relative depletion of epithelial cells. In infected mice, APOE2 mice showed enrichment of pathways implicated in immune activation, consistent with immunologic misfiring.

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-07 | GSE184289 | GEO

Two distinct immunopathological profiles in lungs of lethal COVID-19

Project description:Immune responses in lungs of Coronavirus Disease 2019 (COVID-19) are poorly characterized. We conducted transcriptomic, histologic and cellular profiling of post mortem COVID-19 and normal lung tissues. Two distinct immunopathological reaction patterns were identified. One pattern showed high expression of interferon stimulated genes (ISGs) and cytokines, high viral loads and limited pulmonary damage, the other pattern showed severely damaged lungs, low ISGs, low viral loads and abundant immune infiltrates. Distinct patterns of pulmonary COVID-19 immune responses correlated to hospitalization time and may guide treatment and vaccination approaches.

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