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CACYBP is required for epidermal homeostasis

ABSTRACT: CACYBP is required for epidermal homeostasis

PROVIDER: PRJNA788765 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17227334_1.fastq.gz	Fastqsanger.gz
	SRR17227334_2.fastq.gz	Fastqsanger.gz
	SRR17227335_1.fastq.gz	Fastqsanger.gz
	SRR17227335_2.fastq.gz	Fastqsanger.gz
	SRR17227336_1.fastq.gz	Fastqsanger.gz

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CACYBP is required for epidermal homeostasis

Project description:RNA-seq was used to define the role of CACYBP in epidermal differentiation by first employing CRISPR/Cas9 to disrupt CACYBP with two independent single guide RNAs (sgRNAs) to create pools of CACYBP-ablated primary human keratinocytes that were immortalized with HPV E6/E7 and then placed onto human dermis and grown for three days at the air-liquid interface to generate organotypic skin tissue.

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