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Gene expression profiles in the cultured dorsal root ganglia (DRG) neurons treated with PBS or oncomodulin (ONCM)

ABSTRACT: Gene expression profiles in the cultured dorsal root ganglia (DRG) neurons treated with PBS or oncomodulin (ONCM)

PROVIDER: PRJNA798679 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17662053_1.fastq.gz	Fastqsanger.gz
	SRR17662053_2.fastq.gz	Fastqsanger.gz
	SRR17662054_1.fastq.gz	Fastqsanger.gz
	SRR17662054_2.fastq.gz	Fastqsanger.gz
	SRR17662055_1.fastq.gz	Fastqsanger.gz

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Gene expression profiles in the cultured dorsal root ganglia (DRG) neurons treated with PBS or oncomodulin (ONCM)

Project description:Preconditioning nerve injury drives pro-regenerative perineuronal macrophage activation in dorsal root ganglia (DRG). The present study reports that oncomodulin (ONCM) is produced from the regeneration-associated macrophages (RAMs) and strongly influences regeneration of DRG sensory axons. ONCM in macrophages was necessary to produce RAMs in the in vitro model of neuron-macrophage interaction and played an essential role in for preconditioning-induced neurite outgrowth. In order to gain insight on potential mechanisms downstream of ONCM for potent neurite outgrowth activity, we performed RNA-seq using cultured DRG neurons treated with ONCM.

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