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Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells [Hi-C]

ABSTRACT: Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells [Hi-C]

PROVIDER: PRJNA832332 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18933128_1.fastq.gz	Fastqsanger.gz
	SRR18933128_2.fastq.gz	Fastqsanger.gz
	SRR18933129_1.fastq.gz	Fastqsanger.gz
	SRR18933129_2.fastq.gz	Fastqsanger.gz
	SRR18933130_1.fastq.gz	Fastqsanger.gz

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Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells

Project description:Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells

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Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells [RNA-seq]

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Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells [ATAC-seq]

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Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells [Hi-C]

Project description:The Egr2 promoter antisense RNA (Egr2-AS-RNA) recruits chromatin remodeling complexes to inhibit Egr2 transcription following peripheral nerve injury. Here we show that the Egr2-AS-RNA modulates chromatin accessibility and serves as scaffold for two distinct histone modification complexes. The Egr2-AS-RNA binds to Ezh2 and Wdr5 and enables coordinate targeting of H3K27me3 and H3K4me3 to promoters of Egr2 and c-Jun. Expression of the AS-RNA results in reorganization of the global chromatin landscape and quantitative changes in loop formation and in contact frequency at domain boundaries exhibiting enrichment for AP-1 binding events. Our results show for the first time that the Egr2 promoter AS-RNA may serve as a regulator of coordinate chromatin remodeling and genome organization to regulate transcription, with a significant role in phenotypic plasticity of SCs.

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Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells [ATAC-seq]

2023-04-14 | GSE201624 | GEO

Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells [RNA-seq]

2023-04-14 | GSE201623 | GEO

Egr2 promoter antisense RNA as coordinator of chromatin remodeling and genome reorganization in Schwann cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-04-14 | GSE201627 | GEO

Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve

Project description:We provide ChIP-Seq analysis of Egr2 and Sox10 transcription factor binding in Schwann cells of rat peripheral nerve ChIP-Seq analysis of Egr2 and Sox10 binding in P15 rat sciatic nerve. Wiggle files of negative log of posterior probability determined by Mosaics.

2012-04-01 | E-GEOD-35132 | biostudies-arrayexpress

Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve

Project description:We provide ChIP-Seq analysis of Egr2 and Sox10 transcription factor binding in Schwann cells of rat peripheral nerve

2012-04-01 | GSE35132 | GEO

RNA-seq of FR4+Egr2+, FR4+Egr2-, FR4-Egr2-, FR4+Egr2-/-Egr3-/- and FR4-Egr2-/-Egr3-/- CD4 T cells

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