Project description:Atherosclerosis (AS) is a multiple factors-involved chronic inflammatory disease in the arterial wall, and is the dominant cause of cardiovascular disease (CVD). Based on this hypothesis, several circRNAs are considered play crucial role in the regulation mRNA expression by competitive binding miRNA response elements. Meanwhile, our previous study found several circRNAs that may be involved in the pathogenesis of AS.However, the molecular mechanisms underlying how circRNA regulates endothelial cells (ECs) abnormal transformation in AS by miRNAs remain unknown.Thus, we indentified the miRNA and mRNA expression profiles and screened DE RNA species after overexpression of two above identified circRNAs through using microarray analysis.

2024-09-18 | GSE205119 | GEO

mRNA microarray related to circRNA in human umbilical vein endothelial cells

2024-09-18 | GSE205120 | GEO

Oxidoreductase transcript data from human umbilical vein endothelial cells

Project description:Oxidoreductase enzymes are critical to redox regulation of intracellular proteins within human cells. We used microarrays to identify which oxidreducatse genes are expressed in unstimulated human umbilical vein endothelial cells. Human umbilical vein endothelial cells were grown under optimal conditions and then RNA extracted and hybridized on Affymetrix microarrays.

2010-06-16 | E-GEOD-22166 | biostudies-arrayexpress

Effect of from Human Umbilical Vein Endothelial Cells

Project description:We profiled global gene expression in primary human umbilical vein endothelial cells to determine the gene expression changes associated with knocking down PKM2 and p53. We identified a p53 dependent transcriptional response that remodels metabolism in cells lacking p53, thus limiting cell growth. Human Umbilical Vein Endothelial Cells were transfected with siRNA duplexes targeting PKM2 and / or p53, RNA was extracted and subjected to RNA sequencing

2016-07-27 | E-GEOD-84877 | biostudies-arrayexpress

MicroRNA expression profile of human umbilical vein endothelial cells treated with Angiogenin (ANG)

Project description:We quantified differential microRNA (miRNA) expression in Human umbilical vein endothelial cells （HUVECs）response to Angiogenin (ANG) treatment.These data were used to determine which miRNAs are altered on ANG in Human umbilical vein endothelial cells.

2016-12-13 | GSE92256 | GEO

RNA-seq of CYR61-treated human umbilical vein endothelial cells

Project description:We assess the effect of CYR61 treatment on the transcriptome of human umbilical vein endothelial cells.

2023-10-18 | GSE222101 | GEO